ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>4-penten-1-yl>amino>-2-oxoethyl>-benzoate

Base Information

Chemical Name:ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>4-penten-1-yl>amino>-2-oxoethyl>-benzoate
CAS No.:219922-23-3
Molecular Formula:C₂₉H₃₈N₂O₄
Molecular Weight:478.632
Hs Code.:

Synonyms:ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>4-penten-1-yl>amino>-2-oxoethyl>-benzoate

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Chemical Property of ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>4-penten-1-yl>amino>-2-oxoethyl>-benzoate

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Technology Process of ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>4-penten-1-yl>amino>-2-oxoethyl>-benzoate

There total 13 articles about ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>4-penten-1-yl>amino>-2-oxoethyl>-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 99469-99-5
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

: 89606-14-4
1-(2-piperidino-phenyl)-4-pentenylamine

: 219922-23-3
ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>4-penten-1-yl>amino>-2-oxoethyl>-benzoate

Guidance literature:: With tetrachloromethane; triethylamine; triphenylphosphine; In acetonitrile; for 15h; Ambient temperature;
DOI:10.1021/jm9810349

Reference yield:

: 72752-52-4
2-(piperidin-1-yl)benzonitrile

: 219922-23-3
ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>4-penten-1-yl>amino>-2-oxoethyl>-benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / H₂, NH₃ / Raney-Ni / methanol / 4 h / 50 °C / 3750.3 Torr

2: 2.) Na₂SO₄ / 1.) RT, 48 h, 2.) Et₂O

3: 1.) LDA / 1.) THF, hexane, -20 deg C, 30 min, 2.) THF, hexane, from -70 deg C to RT, overnight

4: aq. HCl / 0.5 h / 0 °C

5: 58 percent / PPh₃, Et₃N, CCl₄ / acetonitrile / 15 h / Ambient temperature

With hydrogenchloride; tetrachloromethane; ammonia; hydrogen; sodium sulfate; triethylamine; triphenylphosphine; lithium diisopropyl amide; nickel; In methanol; acetonitrile;
DOI:10.1021/jm9810349

Reference yield:

: 110-89-4
piperidine

: 219922-23-3
ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>4-penten-1-yl>amino>-2-oxoethyl>-benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C

2: 100 percent / H₂, NH₃ / Raney-Ni / methanol / 4 h / 50 °C / 3750.3 Torr

3: 2.) Na₂SO₄ / 1.) RT, 48 h, 2.) Et₂O

4: 1.) LDA / 1.) THF, hexane, -20 deg C, 30 min, 2.) THF, hexane, from -70 deg C to RT, overnight

5: aq. HCl / 0.5 h / 0 °C

6: 58 percent / PPh₃, Et₃N, CCl₄ / acetonitrile / 15 h / Ambient temperature

With N-Formylpiperidine; hydrogenchloride; tetrachloromethane; ammonia; hydrogen; sodium sulfate; triethylamine; triphenylphosphine; lithium diisopropyl amide; nickel; In methanol; acetonitrile;
DOI:10.1021/jm9810349