ethyl [[[2-(1-benzyl-3-pyrrolidinyl)amino-5-chlorophenyl](2-fluorophenyl)methylen]amino]acetate

Base Information

Chemical Name:ethyl [[[2-(1-benzyl-3-pyrrolidinyl)amino-5-chlorophenyl](2-fluorophenyl)methylen]amino]acetate
CAS No.:96111-07-8
Molecular Formula:C₂₈H₂₉ClFN₃O₂
Molecular Weight:494.009
Hs Code.:

Synonyms:ethyl [[[2-(1-benzyl-3-pyrrolidinyl)amino-5-chlorophenyl](2-fluorophenyl)methylen]amino]acetate

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Chemical Property of ethyl [[[2-(1-benzyl-3-pyrrolidinyl)amino-5-chlorophenyl](2-fluorophenyl)methylen]amino]acetate

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Technology Process of ethyl [[[2-(1-benzyl-3-pyrrolidinyl)amino-5-chlorophenyl](2-fluorophenyl)methylen]amino]acetate

There total 1 articles about ethyl [[[2-(1-benzyl-3-pyrrolidinyl)amino-5-chlorophenyl](2-fluorophenyl)methylen]amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 623-33-6
glycine ethyl ester hydrochloride

: 96524-59-3
(1-Benzyl-pyrrolidin-3-yl)-{4-chloro-2-[(2-fluoro-phenyl)-imino-methyl]-phenyl}-amine

: 96111-07-8
ethyl [[[2-(1-benzyl-3-pyrrolidinyl)amino-5-chlorophenyl](2-fluorophenyl)methylen]amino]acetate

Guidance literature:: With acetic acid; In ethanol; for 3h; Heating;
DOI:10.1021/jm00383a003

Reference yield:

: 96111-07-8
ethyl [[[2-(1-benzyl-3-pyrrolidinyl)amino-5-chlorophenyl](2-fluorophenyl)methylen]amino]acetate

: 96110-69-9
7-Chloro-5-(2-fluoro-phenyl)-1-(1-methyl-pyrrolidin-3-yl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: TFA / 20 h / Heating

2: CH₂Cl₂ / 0.5 h / Heating

3: methanesulfonic acid, tetrahydrothiophene / 0.5 h / 120 °C

4: 42 percent / H₂ / Raney Ni / H₂O; ethanol; methanol / 2 h / Ambient temperature

With thiophene; methanesulfonic acid; hydrogen; trifluoroacetic acid; nickel; In methanol; ethanol; dichloromethane; water;
DOI:10.1021/jm00383a003

Reference yield:

: 96111-07-8
ethyl [[[2-(1-benzyl-3-pyrrolidinyl)amino-5-chlorophenyl](2-fluorophenyl)methylen]amino]acetate

: 3-[7-Chloro-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-pyrrolidine-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / 20 h / Heating

2: CH₂Cl₂ / 0.5 h / Heating

With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00383a003