(2S,5S,6S)-3-aza-3-(benzyloxycarbonyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-2,7-diphenylheptanoyl amide

Base Information

Chemical Name:(2S,5S,6S)-3-aza-3-(benzyloxycarbonyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-2,7-diphenylheptanoyl amide
CAS No.:500767-28-2
Molecular Formula:C₃₆H₄₆N₄O₇
Molecular Weight:646.784
Hs Code.:

Synonyms:(2S,5S,6S)-3-aza-3-(benzyloxycarbonyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-2,7-diphenylheptanoyl amide

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Chemical Property of (2S,5S,6S)-3-aza-3-(benzyloxycarbonyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-2,7-diphenylheptanoyl amide

Chemical Property:

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Technology Process of (2S,5S,6S)-3-aza-3-(benzyloxycarbonyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-2,7-diphenylheptanoyl amide

There total 5 articles about (2S,5S,6S)-3-aza-3-(benzyloxycarbonyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-2,7-diphenylheptanoyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-41-3
t-Boc-L-valine

: ((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-((S)-carbamoyl-phenyl-methyl)-carbamic acid benzyl ester

: 500767-28-2
(2S,5S,6S)-3-aza-3-(benzyloxycarbonyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-2,7-diphenylheptanoyl amide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm020951i

Reference yield:

: 6485-52-5
L-phenylglycine amide

: 500767-28-2
(2S,5S,6S)-3-aza-3-(benzyloxycarbonyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-2,7-diphenylheptanoyl amide

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / propan-2-ol / Heating

2: 85 percent / aq. K₂CO₃ / tetrahydrofuran / 20 °C

3: HCl / ethyl acetate / 20 °C

4: 280 mg / TBTU; DIEA / dimethylformamide / 20 °C

With hydrogenchloride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm020951i

Reference yield:

: 98760-08-8
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

: 500767-28-2
(2S,5S,6S)-3-aza-3-(benzyloxycarbonyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-2,7-diphenylheptanoyl amide

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / propan-2-ol / Heating

2: 85 percent / aq. K₂CO₃ / tetrahydrofuran / 20 °C

3: HCl / ethyl acetate / 20 °C

4: 280 mg / TBTU; DIEA / dimethylformamide / 20 °C

With hydrogenchloride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm020951i