(2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-2,7-diphenylheptanoyl amide

Base Information

Chemical Name:(2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-2,7-diphenylheptanoyl amide
CAS No.:500767-14-6
Molecular Formula:C₂₃H₃₁N₃O₄
Molecular Weight:413.517
Hs Code.:

Synonyms:(2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-2,7-diphenylheptanoyl amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-2,7-diphenylheptanoyl amide

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Technology Process of (2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-2,7-diphenylheptanoyl amide

There total 1 articles about (2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-2,7-diphenylheptanoyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 6485-52-5
L-phenylglycine amide

: 98760-08-8
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

: 500767-14-6
(2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-2,7-diphenylheptanoyl amide

Guidance literature:: In isopropyl alcohol; Heating;
DOI:10.1021/jm020951i

Reference yield: 85.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 500767-14-6
(2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-2,7-diphenylheptanoyl amide

: 500767-21-5
(2S,5S,6S)-3-aza-3-(benzyloxycarbonyl)-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-2,7-diphenylheptanoyl amide

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm020951i

Reference yield:

: 500767-14-6
(2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-2,7-diphenylheptanoyl amide

: 500767-28-2
(2S,5S,6S)-3-aza-3-(benzyloxycarbonyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-2,7-diphenylheptanoyl amide

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / aq. K₂CO₃ / tetrahydrofuran / 20 °C

2: HCl / ethyl acetate / 20 °C

3: 280 mg / TBTU; DIEA / dimethylformamide / 20 °C

With hydrogenchloride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020951i