((2S,3R,4S)-3-(benzyloxy)-4-(benzyloxymethyl)-1-butylazetidin-2-yl)methanol

Base Information

Chemical Name:((2S,3R,4S)-3-(benzyloxy)-4-(benzyloxymethyl)-1-butylazetidin-2-yl)methanol
CAS No.:1366422-94-7
Molecular Formula:C₂₃H₃₁NO₃
Molecular Weight:369.504
Hs Code.:

Synonyms:((2S,3R,4S)-3-(benzyloxy)-4-(benzyloxymethyl)-1-butylazetidin-2-yl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((2S,3R,4S)-3-(benzyloxy)-4-(benzyloxymethyl)-1-butylazetidin-2-yl)methanol

Chemical Property:

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Technology Process of ((2S,3R,4S)-3-(benzyloxy)-4-(benzyloxymethyl)-1-butylazetidin-2-yl)methanol

There total 10 articles about ((2S,3R,4S)-3-(benzyloxy)-4-(benzyloxymethyl)-1-butylazetidin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 110-62-3
pentanal

: 1366422-92-5
(2S,3S,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tert-butyldimethylsilyloxy)methyl)azetidine

: 1366422-94-7
((2S,3R,4S)-3-(benzyloxy)-4-(benzyloxymethyl)-1-butylazetidin-2-yl)methanol

Guidance literature:: pentanal; (2S,3S,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tert-butyldimethylsilyloxy)methyl)azetidine; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 16h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jo202054g

Reference yield:

: C₂₉H₄₅NO₃Si

: 1366422-94-7
((2S,3R,4S)-3-(benzyloxy)-4-(benzyloxymethyl)-1-butylazetidin-2-yl)methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 221216-58-6
N-((1S,2S,3R)-2-Benzyloxy-1-benzyloxymethyl-3,4-dihydroxy-butyl)-4-methyl-benzenesulfonamide

: 1366422-94-7
((2S,3R,4S)-3-(benzyloxy)-4-(benzyloxymethyl)-1-butylazetidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; dmap / dichloromethane

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 20 °C

2.2: -60 °C

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With dmap; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;