(2S,3S,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tert-butyldimethylsilyloxy)methyl)azetidine

Base Information

Chemical Name:(2S,3S,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tert-butyldimethylsilyloxy)methyl)azetidine
CAS No.:1366422-92-5
Molecular Formula:C₂₅H₃₇NO₃Si
Molecular Weight:427.659
Hs Code.:

Synonyms:(2S,3S,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tert-butyldimethylsilyloxy)methyl)azetidine

Suppliers and Price of (2S,3S,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tert-butyldimethylsilyloxy)methyl)azetidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tert-butyldimethylsilyloxy)methyl)azetidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tert-butyldimethylsilyloxy)methyl)azetidine

There total 10 articles about (2S,3S,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tert-butyldimethylsilyloxy)methyl)azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 221216-64-4
N-((2S,3S,4R)-1,3-bis(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-hydroxypentan-2-yl)-4-methylbenzenesulfonamide

: 1366422-92-5
(2S,3S,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tert-butyldimethylsilyloxy)methyl)azetidine

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: naphthalene; sodium / 1,2-dimethoxyethane / -60 °C / Inert atmosphere

With naphthalene; di-isopropyl azodicarboxylate; sodium; triphenylphosphine; In 1,2-dimethoxyethane; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1021/jo202054g

Reference yield:

: 221216-70-2
(2S,3S,4S)-3-Benzyloxy-2-benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-azetidine

: 1366422-92-5
(2S,3S,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tert-butyldimethylsilyloxy)methyl)azetidine

Guidance literature:: With naphthalene; sodium; In 1,2-dimethoxyethane; at -60 ℃; Inert atmosphere;
DOI:10.1021/jo202054g

Reference yield:

: 221276-73-9
(1S,2S)-2-Azido-3-benzyloxy-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propan-1-ol

: 1366422-92-5
(2S,3S,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tert-butyldimethylsilyloxy)methyl)azetidine

Guidance literature:: Multi-step reaction with 7 steps

1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / -78 - 0 °C / Inert atmosphere

3: triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

4: hydrogenchloride; water / methanol / 40 °C

5: dmap; triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

6: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere

7: naphthalene; sodium / 1,2-dimethoxyethane / -60 °C / Inert atmosphere

With hydrogenchloride; dmap; lithium aluminium tetrahydride; naphthalene; di-isopropyl azodicarboxylate; water; sodium; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; mineral oil; 6: Mitsunobu reaction;
DOI:10.1021/jo202054g