acetic acid 6a-(2-bromo-phenyl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,2-b]furan-3-yl ester

Base Information

Chemical Name:acetic acid 6a-(2-bromo-phenyl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,2-b]furan-3-yl ester
CAS No.:881424-01-7
Molecular Formula:C₃₆H₃₉BrN₂O₇Si
Molecular Weight:719.704
Hs Code.:

acetic acid 6a-(2-bromo-phenyl)-2-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-hexahydro-furo[3,2-<i>b</i>]furan-3-yl ester

Synonyms:acetic acid 6a-(2-bromo-phenyl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,2-b]furan-3-yl ester

Suppliers and Price of acetic acid 6a-(2-bromo-phenyl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,2-b]furan-3-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of acetic acid 6a-(2-bromo-phenyl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,2-b]furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of acetic acid 6a-(2-bromo-phenyl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,2-b]furan-3-yl ester

There total 7 articles about acetic acid 6a-(2-bromo-phenyl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,2-b]furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 881423-80-9
(1R,5S,7R,8R)-5-(2-bromophenyl)-7-[(tert-butyldiphenylsilyloxy)methyl]-2,6-dioxabicyclo[3.3.0]octane-3,8-diyl diacetate

: 65-71-4,28806-14-6,691841-57-3
thymin

: acetic acid 6a-(2-bromo-phenyl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,2-b]furan-3-yl ester

: 881424-01-7
acetic acid 6a-(2-bromo-phenyl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,2-b]furan-3-yl ester

Guidance literature:: With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/jo052413u

Reference yield:

: 881423-76-3
1-(2-bromophenyl)-5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose

: 881424-01-7
acetic acid 6a-(2-bromo-phenyl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,2-b]furan-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: ZnBr₂ / nitromethane / 0 - 20 °C

2: OsO₄; NaIO₄; pyridine / H₂O / 30 h / 20 °C

3: H₂SO₄ / tetrahydrofuran; H₂O / 12 h / 60 °C

4: 663 mg / pyridine / 0 - 20 °C

5: 62 percent / trimethylsilyl N-(trimethylsilyl)acetimidate; TMSOTf / acetonitrile / 1 h / 20 °C

With pyridine; sodium periodate; osmium(VIII) oxide; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; zinc dibromide; In tetrahydrofuran; nitromethane; water; acetonitrile;
DOI:10.1021/jo052413u

Reference yield:

: [4-(2-bromo-phenyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-acetaldehyde

: 881424-01-7
acetic acid 6a-(2-bromo-phenyl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,2-b]furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂SO₄ / tetrahydrofuran; H₂O / 12 h / 60 °C

2: 663 mg / pyridine / 0 - 20 °C

3: 62 percent / trimethylsilyl N-(trimethylsilyl)acetimidate; TMSOTf / acetonitrile / 1 h / 20 °C

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jo052413u