4-(4-(3-(2-(1-methylethoxy)phenoxy)propyl)piperazin-1-yl)-1-(phenylsulphonyl)-1H-indole

Base Information

Chemical Name:4-(4-(3-(2-(1-methylethoxy)phenoxy)propyl)piperazin-1-yl)-1-(phenylsulphonyl)-1H-indole
CAS No.:1416970-54-1
Molecular Formula:C₃₀H₃₅N₃O₄S
Molecular Weight:533.692
Hs Code.:

Synonyms:4-(4-(3-(2-(1-methylethoxy)phenoxy)propyl)piperazin-1-yl)-1-(phenylsulphonyl)-1H-indole

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Chemical Property of 4-(4-(3-(2-(1-methylethoxy)phenoxy)propyl)piperazin-1-yl)-1-(phenylsulphonyl)-1H-indole

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Technology Process of 4-(4-(3-(2-(1-methylethoxy)phenoxy)propyl)piperazin-1-yl)-1-(phenylsulphonyl)-1H-indole

There total 5 articles about 4-(4-(3-(2-(1-methylethoxy)phenoxy)propyl)piperazin-1-yl)-1-(phenylsulphonyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1-(phenylsulfonyl)-4-(1-piperazinyl)-1H-indole hydrochloride

: 117022-42-1
1-(3-chloropropoxy)-2-(1-methylethoxy)benzene

: 1416970-54-1
4-(4-(3-(2-(1-methylethoxy)phenoxy)propyl)piperazin-1-yl)-1-(phenylsulphonyl)-1H-indole

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 8h;
DOI:10.1016/j.physbeh.2013.05.042

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1416970-54-1
4-(4-(3-(2-(1-methylethoxy)phenoxy)propyl)piperazin-1-yl)-1-(phenylsulphonyl)-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 0.33 h / 0 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C

3.1: potassium iodide; potassium carbonate / acetonitrile / 12 h / 70 °C

With hydrogenchloride; 18-crown-6 ether; potassium tert-butylate; potassium carbonate; potassium iodide; In tetrahydrofuran; 1,4-dioxane; acetonitrile;

Reference yield:

: 393508-48-0
4-(1-benzenesulfonyl-1H-indol-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1416970-54-1
4-(4-(3-(2-(1-methylethoxy)phenoxy)propyl)piperazin-1-yl)-1-(phenylsulphonyl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C

2: potassium iodide; potassium carbonate / acetonitrile / 12 h / 70 °C

With hydrogenchloride; potassium carbonate; potassium iodide; In 1,4-dioxane; acetonitrile;