1-[3-[(4-BroMophenyl)sulfonyl]-2-quinoxalinyl]-4-piperidinol

Base Information

Chemical Name:1-[3-[(4-BroMophenyl)sulfonyl]-2-quinoxalinyl]-4-piperidinol
CAS No.:1350960-66-5
Molecular Formula:C₁₉H₁₈BrN₃O₃S
Molecular Weight:448.34
Hs Code.:
Mol file:1350960-66-5.mol

Synonyms:2-(4-hydroxypiperidin-1-yl)-3-(4-bromophenylsulfonyl)quinoxaline

Suppliers and Price of 1-[3-[(4-BroMophenyl)sulfonyl]-2-quinoxalinyl]-4-piperidinol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-[3-[(4-Bromophenyl)sulfonyl]-2-quinoxalinyl]-4-piperidinol
100mg
$ 1470.00

Matrix Scientific
1-(3-(4-Bromophenylsulfonyl)quinoxalin-2-yl)piperidin-4-ol 95%
5g
$ 3256.00

Matrix Scientific
1-(3-(4-Bromophenylsulfonyl)quinoxalin-2-yl)piperidin-4-ol 95%
1g
$ 1018.00

Total 3 raw suppliers

Chemical Property of 1-[3-[(4-BroMophenyl)sulfonyl]-2-quinoxalinyl]-4-piperidinol

Chemical Property:

Boiling Point:654.9±55.0 °C(Predicted)
PKA:14.36±0.20(Predicted)
Density:1.579±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

1-[3-[(4-Bromophenyl)sulfonyl]-2-quinoxalinyl]-4-piperidinol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 1-[3-[(4-Bromophenyl)sulfonyl]-2-quinoxalinyl]-4-piperidinol is a novel PI3Ka inhibitors which demonstrated excellent antitumor activities against five human cell lines.

Technology Process of 1-[3-[(4-BroMophenyl)sulfonyl]-2-quinoxalinyl]-4-piperidinol

There total 3 articles about 1-[3-[(4-BroMophenyl)sulfonyl]-2-quinoxalinyl]-4-piperidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1083236-25-2
2-choloro-3-(4-bromophenylsulfonyl)quinoxaline

: 1350960-66-5
2-(4-hydroxypiperidin-1-yl)-3-(4-bromophenylsulfonyl)quinoxaline

Guidance literature:: In isopropyl alcohol; at 80 ℃; for 0.166667h; Microwave irradiation; Sealed vessel;
DOI:10.1016/j.bmc.2012.03.026

Reference yield:

: 98-58-8
4-bromobenzenesulfonyl chloride

: 1350960-66-5
2-(4-hydroxypiperidin-1-yl)-3-(4-bromophenylsulfonyl)quinoxaline

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / water / 0 - 20 °C

2: ethanol / Reflux

3: isopropyl alcohol / 0.17 h / 80 °C / Microwave irradiation; Sealed vessel

With hydrazine hydrate; In ethanol; water; isopropyl alcohol;
DOI:10.1016/j.bmc.2012.03.026

Reference yield:

: 2297-64-5
p-bromophenylsulfonyl hydrazide

: 1350960-66-5
2-(4-hydroxypiperidin-1-yl)-3-(4-bromophenylsulfonyl)quinoxaline

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / Reflux

2: isopropyl alcohol / 0.17 h / 80 °C / Microwave irradiation; Sealed vessel

In ethanol; isopropyl alcohol;
DOI:10.1016/j.bmc.2012.03.026