8?chloro?6?(2?fluorophenyl)?1?methyl?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine

Base Information

Chemical Name:8?chloro?6?(2?fluorophenyl)?1?methyl?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine
CAS No.:819793-80-1
Molecular Formula:C₂₅H₁₉ClFN₃O₂S
Molecular Weight:479.962
Hs Code.:

Synonyms:8?chloro?6?(2?fluorophenyl)?1?methyl?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine

Suppliers and Price of 8?chloro?6?(2?fluorophenyl)?1?methyl?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8?chloro?6?(2?fluorophenyl)?1?methyl?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 8?chloro?6?(2?fluorophenyl)?1?methyl?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine

There total 8 articles about 8?chloro?6?(2?fluorophenyl)?1?methyl?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 74-88-4
methyl iodide

: 819793-75-4
8?chloro?6?(2?fluorophenyl)?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine

: 819793-80-1
8?chloro?6?(2?fluorophenyl)?1?methyl?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine

Guidance literature:: 8?chloro?6?(2?fluorophenyl)?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

methyl iodide; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1055/s-2004-831243

Reference yield:

: 2886-65-9
7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2(2H)-one

: 819793-80-1
8?chloro?6?(2?fluorophenyl)?1?methyl?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: P₂S₅; NaHCO₃ / acetonitrile / 24 h / Heating

2.1: acetonitrile; H₂O / 3 h / 20 °C

3.1: 0.61 g / sodium nitrite; AcOH / 3 h / 20 °C

4.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

4.2: 82 percent / tetrahydrofuran; hexane / -78 - 20 °C

5.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

5.2: 92 percent / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; tetraphosphorus decasulfide; sodium hydrogencarbonate; acetic acid; sodium nitrite; In tetrahydrofuran; hexane; water; acetonitrile;
DOI:10.1055/s-2004-831243

Reference yield:

: 1645-32-5
7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepine-2-thione

: 819793-80-1
8?chloro?6?(2?fluorophenyl)?1?methyl?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile; H₂O / 3 h / 20 °C

2.1: 0.61 g / sodium nitrite; AcOH / 3 h / 20 °C

3.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

3.2: 82 percent / tetrahydrofuran; hexane / -78 - 20 °C

4.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

4.2: 92 percent / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; acetic acid; sodium nitrite; In tetrahydrofuran; hexane; water; acetonitrile;
DOI:10.1055/s-2004-831243