5-hydroxy-2-(4-chlorophenyl)benzofuran

Base Information

• Chemical Name: 5-hydroxy-2-(4-chlorophenyl)benzofuran
• CAS No.: 1448962-34-2
• Molecular Formula: C₁₄H₉ClO₂
• Molecular Weight: 244.677
• Mol file: 1448962-34-2.mol

Synonyms:5-hydroxy-2-(4-chlorophenyl)benzofuran

Chemical Property of 5-hydroxy-2-(4-chlorophenyl)benzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-hydroxy-2-(4-chlorophenyl)benzofuran

There total 6 articles about 5-hydroxy-2-(4-chlorophenyl)benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-acetoxy-2-(4-chlorophenyl)benzofuran (1448962-19-3) → 5-hydroxy-2-(4-chlorophenyl)benzofuran (1448962-34-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 2h; Reflux;

DOI:10.1016/j.ejmech.2014.05.014

Reference yield: 60.0%

para-chloroacetophenone (99-91-2) + p-benzoquinone (106-51-4) → 5-hydroxy-2-(4-chlorophenyl)benzofuran (1448962-34-2)

Guidance literature:

With orthoformic acid triethyl ester; scandium tris(trifluoromethanesulfonate); In 1,4-dioxane; at 80 ℃; for 1h;

DOI:10.1002/adsc.201600048

Reference yield:

2,5-Dihydroxybenzaldehyde (1194-98-5) → 5-hydroxy-2-(4-chlorophenyl)benzofuran (1448962-34-2)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / diethyl ether / 3 h / 20 °C

2: sodium cyanoborohydride; hydrogenchloride; acetic acid / water; tetrahydrofuran / 16 h / 70 °C / pH Ca_. 3

3: triphenylphosphine hydrobromide / acetonitrile / 3 h / Reflux

4: triethylamine / toluene / Reflux

5: potassium hydroxide / ethanol / 2 h / Reflux

With hydrogenchloride; triphenylphosphine hydrobromide; sodium cyanoborohydride; potassium carbonate; acetic acid; triethylamine; potassium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; water; toluene; acetonitrile; 4: |Wittig Olefination;

DOI:10.1016/j.ejmech.2014.05.014

upstream raw materials:

2,5-Dihydroxybenzaldehyde

2-formyl-1,4-phenylene diacetate

5-acetoxy-2-hydroxybenzyl acetate

5-acetoxy-2-hydroxybenzyltriphenylphosphonium bromide

Downstream raw materials:

4-([1,4'-bipiperidin]-1'-ylmethyl)-2-(4-chlorophenyl)benzofuran-5-ol