3-[(5-cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carbonyl)-amino]-benzoic acid benzyl ester

Base Information

Chemical Name:3-[(5-cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carbonyl)-amino]-benzoic acid benzyl ester
CAS No.:1027063-99-5
Molecular Formula:C₃₆H₃₅N₃O₃
Molecular Weight:557.692
Hs Code.:

3-[(5-cycloheptylmethyl-2-naphthalen-2-yl-1<i>H</i>-imidazole-4-carbonyl)-amino]-benzoic acid benzyl ester

Synonyms:3-[(5-cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carbonyl)-amino]-benzoic acid benzyl ester

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Chemical Property of 3-[(5-cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carbonyl)-amino]-benzoic acid benzyl ester

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Technology Process of 3-[(5-cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carbonyl)-amino]-benzoic acid benzyl ester

There total 5 articles about 3-[(5-cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carbonyl)-amino]-benzoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 269070-87-3
5-cycloheptylmethyl-2-(naphthalen-2-yl)-1H-imidazole-4-carboxylic acid

: 80787-43-5
3-aminobenzoic acid benzyl ester

: 1027063-99-5
3-[(5-cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carbonyl)-amino]-benzoic acid benzyl ester

Guidance literature:: With dmap; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm049069y

Reference yield:

: 269070-85-1
4-cycloheptyl-2,3-dioxobutyric acid ethyl ester

: 1027063-99-5
3-[(5-cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carbonyl)-amino]-benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / NH₄OAc; AcOH / 2 h / 70 °C

2: 96 percent / aq. NaOH / ethanol / 48 h / Heating

3: HOBT; DMAP; EDC / dimethylformamide / 20 °C

With dmap; sodium hydroxide; ammonium acetate; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm049069y

Reference yield:

: 269070-86-2
5-Cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carboxylic Acid Ethyl Ester

: 1027063-99-5
3-[(5-cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carbonyl)-amino]-benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / aq. NaOH / ethanol / 48 h / Heating

2: HOBT; DMAP; EDC / dimethylformamide / 20 °C

With dmap; sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm049069y