(8S,20R)-des-A,B-8-benzoyloxy-20-[4'-(tertbutyldimethylsilyloxy)-4'-methyl-pent-(1'E)-en-yl]-pregnane

Base Information

Chemical Name:(8S,20R)-des-A,B-8-benzoyloxy-20-[4'-(tertbutyldimethylsilyloxy)-4'-methyl-pent-(1'E)-en-yl]-pregnane
CAS No.:1588410-78-9
Molecular Formula:C₃₁H₅₀O₃Si
Molecular Weight:498.822
Hs Code.:

Synonyms:(8S,20R)-des-A,B-8-benzoyloxy-20-[4'-(tertbutyldimethylsilyloxy)-4'-methyl-pent-(1'E)-en-yl]-pregnane

Suppliers and Price of (8S,20R)-des-A,B-8-benzoyloxy-20-[4'-(tertbutyldimethylsilyloxy)-4'-methyl-pent-(1'E)-en-yl]-pregnane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (8S,20R)-des-A,B-8-benzoyloxy-20-[4'-(tertbutyldimethylsilyloxy)-4'-methyl-pent-(1'E)-en-yl]-pregnane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (8S,20R)-des-A,B-8-benzoyloxy-20-[4'-(tertbutyldimethylsilyloxy)-4'-methyl-pent-(1'E)-en-yl]-pregnane

There total 3 articles about (8S,20R)-des-A,B-8-benzoyloxy-20-[4'-(tertbutyldimethylsilyloxy)-4'-methyl-pent-(1'E)-en-yl]-pregnane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 1588410-77-8
(8S,20R)-des-A,B-8-benzoyloxy-20-[4'-hydroxy-4'-methylpent-(1'E)-en-yl]-pregnane

: 1588410-78-9
(8S,20R)-des-A,B-8-benzoyloxy-20-[4'-(tertbutyldimethylsilyloxy)-4'-methyl-pent-(1'E)-en-yl]-pregnane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -20 - 0 ℃; for 1h;
DOI:10.1016/j.steroids.2014.01.012

Reference yield:

: 66774-71-8
Benzoic acid (1R,3aR,4S,7aR)-7a-methyl-1-((S)-1-methyl-2-oxo-ethyl)-octahydro-inden-4-yl ester

: 1588410-78-9
(8S,20R)-des-A,B-8-benzoyloxy-20-[4'-(tertbutyldimethylsilyloxy)-4'-methyl-pent-(1'E)-en-yl]-pregnane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -20 °C

1.2: 22 h / -20 - 20 °C

2.1: 2,6-dimethylpyridine / dichloromethane / 1 h / -20 - 0 °C

With 2,6-dimethylpyridine; n-butyllithium; In tetrahydrofuran; dichloromethane; 1.1: |Wittig Olefination / 1.2: |Wittig Olefination;
DOI:10.1016/j.steroids.2014.01.012

Reference yield:

: 67883-18-5
(3-Hydroxy-3-methylbutyl)triphenylphosphoniumbromid

: 1588410-78-9
(8S,20R)-des-A,B-8-benzoyloxy-20-[4'-(tertbutyldimethylsilyloxy)-4'-methyl-pent-(1'E)-en-yl]-pregnane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -20 °C

1.2: 22 h / -20 - 20 °C

2.1: 2,6-dimethylpyridine / dichloromethane / 1 h / -20 - 0 °C

With 2,6-dimethylpyridine; n-butyllithium; In tetrahydrofuran; dichloromethane; 1.1: |Wittig Olefination / 1.2: |Wittig Olefination;
DOI:10.1016/j.steroids.2014.01.012