66774-71-8

Usage

InChI:InChI=1/C20H26O3/c1-14(13-21)16-10-11-17-18(9-6-12-20(16,17)2)23-19(22)15-7-4-3-5-8-15/h3-5,7-8,13-14,16-18H,6,9-12H2,1-2H3/t14-,16?,17?,18+,20-/m1/s1

Upstream product

• 68702-86-3 (24R,22E)-des-A,B-8β-(benzoyloxy)ergost-22-ene 
• 98-88-4 benzoyl chloride 
• 68702-86-3 Benzoic acid (1R,3aR,7aR)-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl ester 
• 55812-82-3 (1R,3aR,7aR)-7a-Methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ol 
• 66774-71-8 Benzoic acid (1R,3aR,7aR)-7a-methyl-1-((S)-1-methyl-2-oxo-ethyl)-octahydro-inden-4-yl ester 
• 66774-80-9 (S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate 
• 55812-82-3 (1R,3aR,4S,7aR)-7a-methyl-1-<(2E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl>-octahydro-1H-inden-4-ol 
• 50-14-6 Calciferol 
• 64190-52-9 (8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol 
• 64190-53-0 (S)-2-((1R,3aR,4S,7aR)-4-(benzoyloxy)-7a-methyloctahydro-1H-inden-1-yl)propyl benzoate 
• 100858-19-3 de-A,B-8β-(benzoyloxy)-23,24-dinor-22-(tosyloxy)cholane 
• 66774-70-7 (8S,20S)-des-A,B-8-benzoyloxy-20-(hydroxymethyl)-pregnane 

Downstream Products

• 1283571-16-3 (8S,20S)-des-A,B-8-benzoyloxy-20-[4'-hydroxy-4'-methylpent-(1'E)-en-yl]-pregnane 
• 1283571-18-5 (8S,20S)-des-A,B-8-benzoyloxy-20-[4'-(tertbutyldimethylsilyloxy)-4'-methyl-pent-(1'E)-en-yl]-pregnane 
• 66774-71-8 Benzoic acid (1R,3aR,7aR)-7a-methyl-1-((R)-1-methyl-2-oxo-ethyl)-octahydro-inden-4-yl ester 
• 68702-85-2 Benzoic acid (1R,3aR,4S,7aR)-1-((1S,4R)-2-acetoxy-3-benzenesulfonyl-1,4,5-trimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl ester 
• 115527-13-4 Benzoic acid (1R,3aR,7aR)-1-((R)-1-[1,3]dioxan-2-yl-ethyl)-7a-methyl-octahydro-inden-4-yl ester 
• 115527-18-9 Benzoic acid (1R,3aR,7aR)-1-[(1S,2S)-5-hydroxy-2-((1R,3R)-3-hydroxy-1-methyl-butoxy)-1,5-dimethyl-hex-3-ynyl]-7a-methyl-octahydro-inden-4-yl ester 
• 115527-18-9 Benzoic acid (1R,3aR,7aR)-1-[(1S,2R)-5-hydroxy-2-((1R,3R)-3-hydroxy-1-methyl-butoxy)-1,5-dimethyl-hex-3-ynyl]-7a-methyl-octahydro-inden-4-yl ester 
• 115527-20-3 Benzoic acid (1R,3aR,7aR)-1-[(1S,2R)-5-methoxymethoxy-1,5-dimethyl-2-((R)-1-methyl-3-oxo-butoxy)-hex-3-ynyl]-7a-methyl-octahydro-inden-4-yl ester 
• 115527-21-4 Benzoic acid (1R,3aR,7aR)-1-((Z)-(1S,2S)-2-carbamoyloxy-5-methoxymethoxy-1,5-dimethyl-hex-3-enyl)-7a-methyl-octahydro-inden-4-yl ester 
• 115527-19-0 Benzoic acid (1R,3aR,7aR)-1-[(1S,2R)-5-hydroxy-1,5-dimethyl-2-((R)-1-methyl-3-oxo-butoxy)-hex-3-ynyl]-7a-methyl-octahydro-inden-4-yl ester 
• 115527-17-8 Benzoic acid (1R,3aR,7aR)-1-[(S)-5-hydroxy-2-(3-hydroxy-propoxy)-1,5-dimethyl-hex-3-ynyl]-7a-methyl-octahydro-inden-4-yl ester 
• 100858-20-6 Benzoic acid (1R,3aR,7aR)-1-((1S,2R)-2-hydroxy-5-methoxymethoxy-1,5-dimethyl-hex-3-ynyl)-7a-methyl-octahydro-inden-4-yl ester 
• 115527-13-4 Benzoic acid (1R,3aR,7aR)-1-((S)-1-[1,3]dioxan-2-yl-ethyl)-7a-methyl-octahydro-inden-4-yl ester 
• 115527-14-5 Benzoic acid (1R,3aR,7aR)-1-[(R)-1-((4R,6R)-4,6-dimethyl-[1,3]dioxan-2-yl)-ethyl]-7a-methyl-octahydro-inden-4-yl ester 

Relevant academic research and scientific papers

2alpha-Methyl and 2beta-Methyl Analogs of 19,26-Dinor-1alpha,25-Dihydroxyvitamin D3 and Their Uses

This invention discloses 2α-methyl and 2β-methyl analogs of 19,26-dinor-1α,25-dihydroxyvitamin D3 and pharmaceutical uses therefor. These compounds exhibit in vitro biological activities evidencing use as an anti-cancer agent and for the treatm

(20S,22E)-2-METHYLENE-19-NOR-22-ENE-1&α,25-DIHYDROXYVITAMIN D3 ANALOGS

This invention discloses (20S.22E)-2-mcthylenc-19-nor-22-enc-1α,25- dihydroxyvitamin D3 analogs, and specifically(20S,22E)-2 -methylene- 19-nor-22-ene- 1 α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhib

2-METHYLENE-19,26-NOR-(20S)-1α-HYDROXYVITAMIN D3

Compounds of formula I are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are useful in treating a variety of biologica

Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D3 markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription

Twelve new analogues of 19-nor-1α,25-dihydroxyvitamin D3 (5-16) were prepared by convergent syntheses, employing the Wittig Horner reaction. The necessary Grundmann type ketones (45-48), possessing fixed configurations of the hydroxyl group at

2-Methylene-19,26-Dinor-(20R,22E,25R)-Vitamin D Analogs

This invention discloses 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs, and specifically 2-methylene-19,26-dinor-(20R,22E,25R)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits transcription activity

2-Methylene-19,26-Dinor-(20S,22E,25R)-Vitamin D Analogs

This invention discloses 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs, and specifically 2-methylene-19,26-dinor-(20S,22E,25R)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits transcription activity

2-Methylene-(20S,25R)-19,26-Dinor-Vitamin D Analogs

This invention discloses 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25R)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arrestin

2-Methylene-(20S,25S)-19,26-Dinor-Vitamin D Analogs

This invention discloses 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arrestin

2-Methylene-(20S,25S)-19,27-Dinor-(22E)-Vitamin D Analogs

This invention discloses 2-methylene-(20S,25S)-19,27-dinor-(22E)-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,27-dinor-(22E)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity

2-Methylene-(20R,25S)-19,27-Dinor-(22E)-Vitamin D Analogs

This invention discloses 2-methylene-(20R,25S)-19,27-dinor-(22E)-vitamin D analogs, and specifically 2-methylene-(20R,25S)-19,27-dinor-(22E)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity