2-(Trifluoromethyl)piperidine

Base Information

Chemical Name:2-(Trifluoromethyl)piperidine
CAS No.:154630-93-0
Molecular Formula:C₆H₁₀F₃N
Molecular Weight:153.147
Hs Code.:2933399090
European Community (EC) Number:662-999-5
DSSTox Substance ID:DTXSID70460430
Nikkaji Number:J1.974.431K
Mol file:154630-93-0.mol

Synonyms:2-(trifluoromethyl)piperidine;154630-93-0;2-Trifluoromethylpiperidine;MFCD02663549;(+/-)-2-(TRIFLUOROMETHYL)PIPERIDINE;2-Trifluoromethyl-piperidine;()-2-(Trifluoromethyl)piperidine;SCHEMBL1036841;Piperidine,2-(trifluoromethyl)-;DTXSID70460430;2-(Trifluoromethyl)piperidine, 97%;AC1472;AKOS005144047;AB12058;SB45073;SB45104;CS-11121;SY006005;A3399;CS-0068101;FT-0678660;FT-0681799;EN300-52234;A936912

Suppliers and Price of 2-(Trifluoromethyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(Trifluoromethyl)piperidine
50mg
$ 60.00

Sigma-Aldrich
2-(Trifluoromethyl)piperidine 97%
250mg
$ 59.20

Matrix Scientific
(+/-)-2-(Trifluoromethyl)piperidine 97%
500mg
$ 20.00

Matrix Scientific
(+/-)-2-(Trifluoromethyl)piperidine 97%
1g
$ 29.00

Chemenu
2-(Trifluoromethyl)piperidine 97%
10g
$ 410.00

Chemenu
2-(Trifluoromethyl)piperidine 97%
5g
$ 225.00

Anichem
2-(trifluoromethyl)piperidine >95%
1g
$ 30.00

American Custom Chemicals Corporation
2-(TRIFLUOROMETHYL)PIPERIDINE 95.00%
5G
$ 1206.98

American Custom Chemicals Corporation
2-(TRIFLUOROMETHYL)PIPERIDINE 95.00%
1G
$ 687.23

American Custom Chemicals Corporation
2-(TRIFLUOROMETHYL)PIPERIDINE 95.00%
500MG
$ 463.05

Total 20 raw suppliers

Chemical Property of 2-(Trifluoromethyl)piperidine

Chemical Property:

Vapor Pressure:16.7mmHg at 25°C
Refractive Index:n20/D1.390
Boiling Point:118.4oC at 760 mmHg
PKA:7.74±0.10(Predicted)
Flash Point:25.4oC
PSA：12.03000
Density:1.129g/cm3
LogP:2.01960
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:153.07653381
Heavy Atom Count:10
Complexity:110

Purity/Quality:

98% ^*data from raw suppliers

2-(Trifluoromethyl)piperidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,N,Xn
Statements: 10-22-36/37/38-50
Safety Statements: 26-36/37/39-45-61

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCNC(C1)C(F)(F)F

Technology Process of 2-(Trifluoromethyl)piperidine

There total 6 articles about 2-(Trifluoromethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (+/-)-7-(trifluoromethyl)-1,4-dithia-8-azaspiro[5.4]decane

: 154630-93-0,154727-51-2
(+/-)-2-(trifluoromethyl)piperidine

Guidance literature:: W₂ Raney nickel; In ethanol; for 0.5h; Heating;
DOI:10.1002/ejoc.200600157

Reference yield: 71.0%

: 1146222-76-5
6-(trifluoromethyl)-2,3,4,5-tetrahydropyridine

: 154630-93-0,154727-51-2
(+/-)-2-(trifluoromethyl)piperidine

Guidance literature:: With sodium tetrahydroborate; acetic acid; In methanol; at -20 - 20 ℃; Inert atmosphere;
DOI:10.1055/s-0029-1217104

Reference yield: 70.0%

: 368-48-9
2-(trifluoromethyl)pyridine

: 154630-93-0,154727-51-2
(+/-)-2-(trifluoromethyl)piperidine

Guidance literature:: With [Rh(cod)(CI)(CAAC^Me₂)]; hydrogen; In hexane; at 40 ℃; for 24h; diastereoselective reaction; Molecular sieve;
DOI:10.1002/anie.201907457