2-(carbethoxymethoxy)-5-methoxypropiophenone

Base Information

• Chemical Name: 2-(carbethoxymethoxy)-5-methoxypropiophenone
• CAS No.: 29048-58-6
• Molecular Formula: C₁₄H₁₈O₅
• Molecular Weight: 266.294
• Mol file: 29048-58-6.mol

Synonyms:2-(carbethoxymethoxy)-5-methoxypropiophenone

Chemical Property of 2-(carbethoxymethoxy)-5-methoxypropiophenone

Chemical Property:

Purity/Quality:

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Technology Process of 2-(carbethoxymethoxy)-5-methoxypropiophenone

There total 1 articles about 2-(carbethoxymethoxy)-5-methoxypropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(2-hydroxy-5-methoxyphenyl)-1-propanone (49710-99-8) + ethyl bromoacetate (105-36-2) → 2-(carbethoxymethoxy)-5-methoxypropiophenone (29048-58-6)

Guidance literature:

With potassium carbonate; In acetone; for 30h; Inert atmosphere; Reflux;

DOI:10.1021/jm9004225

Reference yield: 9.0%

2-(carbethoxymethoxy)-5-methoxypropiophenone (29048-58-6) → 3-ethyl-5-methoxy-benzofuran (7182-31-2) + 7-methoxy-4-methyl-2,3,4,5-tetrahydro-1-benzoxepine-3,5-dione + (4-Methoxy-2-propionyl-phenoxy)-acetic acid + (2S,3R)-3-Ethyl-3-hydroxy-5-methoxy-2,3-dihydro-benzofuran-2-carboxylic acid ethyl ester

Guidance literature:

With sodium amide; In 1,4-dioxane; at 60 ℃; for 6h; Further byproducts given;

Reference yield:

diethyl 1-cyanomethylphosphonate (2537-48-6) + 2-(carbethoxymethoxy)-5-methoxypropiophenone (29048-58-6) → (E,Z)-2-(carbethoxymethoxy)-5-methoxy-β-ethyl-cinnamonitrile

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1) THF, room temperature, 10 min, 2) THF, 0 deg C, 2 h;

DOI:10.1021/jm00129a031

upstream raw materials:

1-(2-hydroxy-5-methoxyphenyl)-1-propanone

ethyl bromoacetate

Downstream raw materials:

3-ethyl-5-methoxy-benzofuran