tert-butyl (3S)-3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl}-3-(1-trityl-1H-imidazol-4-yl)propanoate

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Chemical Name:tert-butyl (3S)-3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl}-3-(1-trityl-1H-imidazol-4-yl)propanoate
CAS No.:566200-98-4
Molecular Formula:C₄₁H₃₉N₃O₄
Molecular Weight:637.778
Hs Code.:

Synonyms:tert-butyl (3S)-3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl}-3-(1-trityl-1H-imidazol-4-yl)propanoate

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Chemical Property of tert-butyl (3S)-3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl}-3-(1-trityl-1H-imidazol-4-yl)propanoate

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Technology Process of tert-butyl (3S)-3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl}-3-(1-trityl-1H-imidazol-4-yl)propanoate

There total 7 articles about tert-butyl (3S)-3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl}-3-(1-trityl-1H-imidazol-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 337521-39-8
N-methyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide

: 5292-43-3
bromoacetic acid tert-butyl ester

: 566200-98-4
tert-butyl (3S)-3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl}-3-(1-trityl-1H-imidazol-4-yl)propanoate

Guidance literature:: With chloro-trimethyl-silane; zinc; In tetrahydrofuran; at 35 - 40 ℃; for 5h;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at 45 - 67 ℃; for 1.16667h;

N-methyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide; tert-butyl bromozincacetate; With hydrogenchloride; cinchonidine; more than 3 stages;

Reference yield: 95.0%

: 337521-39-8
N-methyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide

: 51656-70-3
(2-tert-butoxy-2-oxoethyl)zinc(II) bromide

: 566200-98-4
tert-butyl (3S)-3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl}-3-(1-trityl-1H-imidazol-4-yl)propanoate

Guidance literature:: With chloro-trimethyl-silane; zinc; In tetrahydrofuran; at 35 - 40 ℃; for 0.0833333h;

With bromoacetic acid tert-butyl ester; In tetrahydrofuran; at 45 - 67 ℃; for 1.16667h;

N-methyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide; tert-butyl bromozincacetate; With hydrogenchloride; cinchonidine; more than 3 stages;

Reference yield:

: 426219-35-4
6-bromo-N-methyl-2-naphthamide

: 566200-98-4
tert-butyl (3S)-3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl}-3-(1-trityl-1H-imidazol-4-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.58 h / -65 °C

1.2: 2.67 h / 65 °C

1.3: -20 - 30 °C

2.1: manganese(IV) oxide / ethyl acetate / 6 h / 40 - 45 °C

3.1: chloro-trimethyl-silane; zinc / tetrahydrofuran / 0.08 h / 35 - 40 °C

3.2: 1.17 h / 45 - 67 °C

With manganese(IV) oxide; n-butyllithium; chloro-trimethyl-silane; zinc; In tetrahydrofuran; hexane; ethyl acetate;