tert-butyl 4-(4-{[(7-cyano-2-napthyl)methyl][(2-ethoxy-2-oxoethyl)sulfonyl]amino}phenyl)-1,4-diazepane-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-{[(7-cyano-2-napthyl)methyl][(2-ethoxy-2-oxoethyl)sulfonyl]amino}phenyl)-1,4-diazepane-1-carboxylate
CAS No.:286430-88-4
Molecular Formula:C₃₂H₃₈N₄O₆S
Molecular Weight:606.743
Hs Code.:

Synonyms:tert-butyl 4-(4-{[(7-cyano-2-napthyl)methyl][(2-ethoxy-2-oxoethyl)sulfonyl]amino}phenyl)-1,4-diazepane-1-carboxylate

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Chemical Property of tert-butyl 4-(4-{[(7-cyano-2-napthyl)methyl][(2-ethoxy-2-oxoethyl)sulfonyl]amino}phenyl)-1,4-diazepane-1-carboxylate

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 4-(4-{[(7-cyano-2-napthyl)methyl][(2-ethoxy-2-oxoethyl)sulfonyl]amino}phenyl)-1,4-diazepane-1-carboxylate

There total 4 articles about tert-butyl 4-(4-{[(7-cyano-2-napthyl)methyl][(2-ethoxy-2-oxoethyl)sulfonyl]amino}phenyl)-1,4-diazepane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 220220-32-6
tert-butyl 4-(4-{[(7-cyano-2-naphthyl)methyl]amino}phenyl)-1,4-diazepane-1-carboxylate

: 286430-88-4
tert-butyl 4-(4-{[(7-cyano-2-napthyl)methyl][(2-ethoxy-2-oxoethyl)sulfonyl]amino}phenyl)-1,4-diazepane-1-carboxylate

Guidance literature:: With pyridine; In 1,2-dichloro-ethane; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2004.02.022

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 286430-88-4
tert-butyl 4-(4-{[(7-cyano-2-napthyl)methyl][(2-ethoxy-2-oxoethyl)sulfonyl]amino}phenyl)-1,4-diazepane-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / potassium carbonate / dimethylformamide / 13 h / 90 °C

2: H₂ / Pd/C / ethanol / 16 h / 20 °C

3: 15.8 g / acetic acid; sodium triacetoxyborohydride / 1,2-dichloro-ethane / 5 h

4: 87 percent / pyridine / 1,2-dichloro-ethane / 12 h / 20 °C

With pyridine; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.02.022

Reference yield:

: 220220-23-5
tert-butyl 4-(4-nitrophenyl)-1,4-diazepane-1-carboxylate

: 286430-88-4
tert-butyl 4-(4-{[(7-cyano-2-napthyl)methyl][(2-ethoxy-2-oxoethyl)sulfonyl]amino}phenyl)-1,4-diazepane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethanol / 16 h / 20 °C

2: 15.8 g / acetic acid; sodium triacetoxyborohydride / 1,2-dichloro-ethane / 5 h

3: 87 percent / pyridine / 1,2-dichloro-ethane / 12 h / 20 °C

With pyridine; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2004.02.022