cis/trans-({3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}oxy)acetic acid tert-butyl ester

Base Information

Chemical Name:cis/trans-({3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}oxy)acetic acid tert-butyl ester
CAS No.:1073136-10-3
Molecular Formula:C₂₄H₂₇BrN₂O₅
Molecular Weight:503.393
Hs Code.:

Synonyms:cis/trans-({3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}oxy)acetic acid tert-butyl ester

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Chemical Property of cis/trans-({3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}oxy)acetic acid tert-butyl ester

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Technology Process of cis/trans-({3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}oxy)acetic acid tert-butyl ester

There total 6 articles about cis/trans-({3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}oxy)acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.2%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1073136-09-0
cis/trans-3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]cyclohexanol

: 1073136-10-3
cis/trans-({3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}oxy)acetic acid tert-butyl ester

Guidance literature:: bromoacetic acid tert-butyl ester; cis/trans-3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]cyclohexanol; With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In water; toluene; at 60 ℃; for 3h;

With hydrogenchloride; In water; toluene;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1073136-10-3
cis/trans-({3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}oxy)acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: diethylamine / N,N-dimethyl-formamide / 20 °C

2: 1.5 h / 210 °C

3: N-Bromosuccinimide / tetrachloromethane / Reflux

4: hydrogenchloride; isopentyl nitrite / 1,4-dioxane; chloroform / Reflux

5: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / toluene; 1,2-dimethoxyethane; water / 1 h / 70 °C

6: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / toluene; water / 3 h / 60 °C

With hydrogenchloride; N-Bromosuccinimide; tetra(n-butyl)ammonium hydrogensulfate; diethylamine; sodium hydroxide; isopentyl nitrite; In 1,4-dioxane; tetrachloromethane; 1,2-dimethoxyethane; chloroform; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 14742-32-6
2-amino-5-phenylfuran-3-carbonitrile

: 1073136-10-3
cis/trans-({3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}oxy)acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.5 h / 210 °C

2: N-Bromosuccinimide / tetrachloromethane / Reflux

3: hydrogenchloride; isopentyl nitrite / 1,4-dioxane; chloroform / Reflux

4: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / toluene; 1,2-dimethoxyethane; water / 1 h / 70 °C

5: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / toluene; water / 3 h / 60 °C

With hydrogenchloride; N-Bromosuccinimide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; isopentyl nitrite; In 1,4-dioxane; tetrachloromethane; 1,2-dimethoxyethane; chloroform; water; toluene;