2-(1-(1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

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Chemical Name:2-(1-(1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid
CAS No.:1404070-16-1
Molecular Formula:C₃₁H₃₄F₃N₃O₃
Molecular Weight:553.624
Hs Code.:

Synonyms:2-(1-(1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

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Chemical Property of 2-(1-(1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

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Technology Process of 2-(1-(1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

There total 2 articles about 2-(1-(1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1404070-17-2
methyl 2-(1-(1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetate

: 1404070-16-1
2-(1-(1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2012.08.034 DOI:10.1016/j.bmc.2012.08.034

Reference yield:

: 128495-46-5
4-fluoro-3-methoxybenzaldehyde

: 1404070-16-1
2-(1-(1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

2: copper(I) bromide / toluene / 24 h / 90 °C / Inert atmosphere; Glovebox; Molecular sieve

3: lithium hydroxide monohydrate / methanol; tetrahydrofuran; water / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; potassium carbonate; copper(I) bromide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2012.08.034 DOI:10.1016/j.bmc.2012.08.034