(-)-(1S,2S,3S,5R)-2-<2-(tetrahydropyran-2-yloxy)ethyl>-3-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>heptane

Base Information

Chemical Name:(-)-(1S,2S,3S,5R)-2-<2-(tetrahydropyran-2-yloxy)ethyl>-3-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>heptane
CAS No.:124264-32-0
Molecular Formula:C₂₂H₃₃NO₄S
Molecular Weight:407.574
Hs Code.:

Synonyms:(-)-(1S,2S,3S,5R)-2-<2-(tetrahydropyran-2-yloxy)ethyl>-3-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>heptane

Suppliers and Price of (-)-(1S,2S,3S,5R)-2-<2-(tetrahydropyran-2-yloxy)ethyl>-3-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>heptane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-(1S,2S,3S,5R)-2-<2-(tetrahydropyran-2-yloxy)ethyl>-3-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>heptane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-(1S,2S,3S,5R)-2-<2-(tetrahydropyran-2-yloxy)ethyl>-3-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>heptane

There total 1 articles about (-)-(1S,2S,3S,5R)-2-<2-(tetrahydropyran-2-yloxy)ethyl>-3-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.7%

: 103080-41-7
(1S,2S,3S,5R)-2-<2-(tetrahydropyran-2-yloxy)ethyl>-3-amino-6,6-dimethylbicyclo<3.1.1>heptane

: 98-09-9
benzenesulfonyl chloride

: 124264-32-0
(-)-(1S,2S,3S,5R)-2-<2-(tetrahydropyran-2-yloxy)ethyl>-3-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>heptane

Guidance literature:: With triethylamine; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1248/cpb.37.948

Reference yield:

: 124264-32-0
(-)-(1S,2S,3S,5R)-2-<2-(tetrahydropyran-2-yloxy)ethyl>-3-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>heptane

: 124264-33-1
(+)-(1S,2S,3S,5R)-2-(2-hydroxyethyl)-3-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>heptane

Guidance literature:: With methanol; toluene-4-sulfonic acid; for 2h; Yield given; Ambient temperature;
DOI:10.1248/cpb.37.948

Reference yield:

: 124264-32-0
(-)-(1S,2S,3S,5R)-2-<2-(tetrahydropyran-2-yloxy)ethyl>-3-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>heptane

: 113007-98-0
(1S,2S,3S,5R)-2-formylmethyl-3-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>heptane

Guidance literature:: Multi-step reaction with 2 steps

1: MeOH / p-TsOH / 2 h / Ambient temperature

2: 1.) DMSO, (COCl)2 3.) Et₃N / 1.) CH₂Cl₂, -50 deg C, 2 min, 2.) DMSO, CH₂Cl₂, -50 deg C, then -15 deg C, 20 min 3.) DMSO, CH₂Cl₂, -50 deg C, 5 min

With methanol; oxalyl dichloride; dimethyl sulfoxide; triethylamine; toluene-4-sulfonic acid;
DOI:10.1248/cpb.37.948