N₅,N₅'-bis(4-ethylphenethyl)-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-1,1',4,4'-tetraoxo-1,1',4,4'-tetrahydro-2,2'-binaphthyl-5,5'-dicarboxamide

Base Information

• Chemical Name: N₅,N₅'-bis(4-ethylphenethyl)-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-1,1',4,4'-tetraoxo-1,1',4,4'-tetrahydro-2,2'-binaphthyl-5,5'-dicarboxamide
• CAS No.: 1256724-02-3
• Molecular Formula: C₄₄H₄₀N₂O₁₀
• Molecular Weight: 756.809
• Mol file: 1256724-02-3.mol

Synonyms:N₅,N₅'-bis(4-ethylphenethyl)-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-1,1',4,4'-tetraoxo-1,1',4,4'-tetrahydro-2,2'-binaphthyl-5,5'-dicarboxamide

Chemical Property of N₅,N₅'-bis(4-ethylphenethyl)-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-1,1',4,4'-tetraoxo-1,1',4,4'-tetrahydro-2,2'-binaphthyl-5,5'-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₅,N₅'-bis(4-ethylphenethyl)-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-1,1',4,4'-tetraoxo-1,1',4,4'-tetrahydro-2,2'-binaphthyl-5,5'-dicarboxamide

There total 6 articles about N₅,N₅'-bis(4-ethylphenethyl)-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-1,1',4,4'-tetraoxo-1,1',4,4'-tetrahydro-2,2'-binaphthyl-5,5'-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

N5,N5'-bis(4-ethylphenethyl)-1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-2,2'-binaphthyl-5,5'-dicarboxamide (1173895-59-4) → N5,N5'-bis(4-ethylphenethyl)-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-1,1',4,4'-tetraoxo-1,1',4,4'-tetrahydro-2,2'-binaphthyl-5,5'-dicarboxamide (1256724-02-3)

Guidance literature:

N₅,N₅'-bis(4-ethylphenethyl)-1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-2,2'-binaphthyl-5,5'-dicarboxamide; With iron(III) chloride; acetic acid; In water; acetone; at 60 - 67 ℃;

With sulfuric acid; In water; acetone;

DOI:10.1021/jm100746q

Reference yield:

N5,N5'-bis(4-ethylphenethyl)-1,1',6,6',7,7'-hexamethoxy-3,3'-dimethyl-2,2'-binaphthyl-5,5'-dicarboxamide (1173895-37-8) → N5,N5'-bis(4-ethylphenethyl)-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-1,1',4,4'-tetraoxo-1,1',4,4'-tetrahydro-2,2'-binaphthyl-5,5'-dicarboxamide (1256724-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane

2: iron(III) chloride; acetic acid / water; acetone / 60 - 67 °C

With iron(III) chloride; boron tribromide; acetic acid; In dichloromethane; water; acetone;

DOI:10.1021/jm100746q

Reference yield:

(rac)-gossypol (303-45-7) → N5,N5'-bis(4-ethylphenethyl)-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-1,1',4,4'-tetraoxo-1,1',4,4'-tetrahydro-2,2'-binaphthyl-5,5'-dicarboxamide (1256724-02-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydroxide / water / 3.5 h / 90 °C / Inert atmosphere; Darkness

2.1: potassium carbonate / acetone / 24 h / Inert atmosphere; Reflux

3.1: titanium tetrachloride / 20 °C

3.2: 20 °C

4.1: sodium chlorite; potassium dihydrogenphosphate; dihydrogen peroxide / acetonitrile / 20 °C

4.2: 20 °C

5.1: boron tribromide / dichloromethane

6.1: iron(III) chloride; acetic acid / water; acetone / 60 - 67 °C

With iron(III) chloride; sodium chlorite; potassium dihydrogenphosphate; dihydrogen peroxide; boron tribromide; titanium tetrachloride; potassium carbonate; acetic acid; sodium hydroxide; In dichloromethane; water; acetone; acetonitrile;

DOI:10.1021/jm100746q

upstream raw materials:

N₅,N₅'-bis(4-ethylphenethyl)-1,1',6,6',7,7'-hexamethoxy-3,3'-dimethyl-2,2'-binaphthyl-5,5'-dicarboxamide

N₅,N₅'-bis(4-ethylphenethyl)-1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-2,2'-binaphthyl-5,5'-dicarboxamide

(rac)-gossypol

apogossypol