Technology Process of α-<(2R,6R)-6-<<(S)-1-carboxy-3-phenylpropyl>amino>-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl>acetic acid
There total 14 articles about α-<(2R,6R)-6-<<(S)-1-carboxy-3-phenylpropyl>amino>-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl>acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
for 16h;
Ambient temperature;
DOI:10.1021/jm00394a009
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C
2: 97 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature
3: 97 percent / NaH / dimethylformamide / 5 h / Ambient temperature
4: 94 percent / 4 N aq. HCl / dioxane / 16 h / Ambient temperature
5: 96 percent / 1 N aq. NaOH / 16 h / Ambient temperature
With
pyridine; hydrogenchloride; sodium hydroxide; sodium hydride; triethylamine;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a009
- Guidance literature:
-
Multi-step reaction with 8 steps
1: N-methylmorpholine / toluene / 16 h / Ambient temperature
2: 51 percent / H2, AcOH / 5percent Pd/C / 5 h / 70 °C / 2280 Torr
3: 78 percent / diphenyl phosphorazidate, N-methylmorpholine / dimethylformamide / 16 h / Ambient temperature
4: 4 N aq. HCl / dioxane / 4 h / Ambient temperature
5: 97 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature
6: 97 percent / NaH / dimethylformamide / 5 h / Ambient temperature
7: 94 percent / 4 N aq. HCl / dioxane / 16 h / Ambient temperature
8: 96 percent / 1 N aq. NaOH / 16 h / Ambient temperature
With
4-methyl-morpholine; hydrogenchloride; sodium hydroxide; diphenyl phosphoryl azide; hydrogen; sodium hydride; acetic acid; triethylamine;
palladium on activated charcoal;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00394a009