(R)-2-[(R)-2-(6-bromo-3-fluoropyridin-2-yl)-2-(4-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide

Base Information

• Chemical Name: (R)-2-[(R)-2-(6-bromo-3-fluoropyridin-2-yl)-2-(4-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide
• CAS No.: 1387561-16-1
• Molecular Formula: C₁₈H₁₇BrF₄N₄O₆S
• Molecular Weight: 573.32
• Mol file: 1387561-16-1.mol

Synonyms:(R)-2-[(R)-2-(6-bromo-3-fluoropyridin-2-yl)-2-(4-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide

Chemical Property of (R)-2-[(R)-2-(6-bromo-3-fluoropyridin-2-yl)-2-(4-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-[(R)-2-(6-bromo-3-fluoropyridin-2-yl)-2-(4-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide

There total 10 articles about (R)-2-[(R)-2-(6-bromo-3-fluoropyridin-2-yl)-2-(4-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N-(2-(6-bromo-3-fluoro-4-(triethylsilyl)pyridin-2-yl)-2-hydroxypropyl)-4-nitrobenzenesulfonamide (1387561-13-8) → (R)-2-[(R)-2-(6-bromo-3-fluoropyridin-2-yl)-2-(4-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide (1387561-16-1)

Guidance literature:

Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 1 h / 4 - 20 °C

2: potassium fluoride; acetic acid / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

3: hydrogenchloride; potassium tert-butylate / N,N-dimethyl-formamide; water / 3.25 h / 25 °C / Inert atmosphere

4: ammonia / methanol / 26 h / 50 °C / Sealed vessel

With hydrogenchloride; potassium fluoride; potassium tert-butylate; ammonia; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

6-bromo-3-fluoro-2-[(2S)-2-methyl-1-(4-nitrobenzenesulfonyl)aziridin-2-yl]pyridine (1387561-15-0) → (R)-2-[(R)-2-(6-bromo-3-fluoropyridin-2-yl)-2-(4-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide (1387561-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; potassium tert-butylate / N,N-dimethyl-formamide; water / 3.25 h / 25 °C / Inert atmosphere

2: ammonia / methanol / 26 h / 50 °C / Sealed vessel

With hydrogenchloride; potassium tert-butylate; ammonia; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

6-bromo-3-fluoro-2-[(2S)-2-methyl-1-(4-nitrobenzenesulfonyl)aziridin-2-yl]-4-triethylsilanylpyridine (1387561-14-9) → (R)-2-[(R)-2-(6-bromo-3-fluoropyridin-2-yl)-2-(4-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide (1387561-16-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium fluoride; acetic acid / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 0.25 °C / Inert atmosphere

2.2: 3 h

3.1: ammonia / methanol / 26 h / 50 °C / Sealed tube

With potassium fluoride; potassium tert-butylate; ammonia; acetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

upstream raw materials:

2-bromo-5-fluoropyridine

2-bromo-5-fluoro-4-triethylsilanylpyridine

1-(6-bromo-3-fluoro-4-(triethylsilyl)pyridin-2-yl)ethan-1-one

(S)-2-(6-bromo-3-fluoro-4-triethylsilanylpyridin-2-yl)-2-trimethylsilanyloxy-propionitrile

Downstream raw materials:

N-[(R)-1-(6-bromo-3-fluoropyridin-2-yl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methylethoxy)-1-methylethyl]-4-nitrobenzenesulfonamide