1-[6-bromo-3-fluoro-4-(triethylsilyl)-2-pyridinyl]Ethanone

Base Information

• Chemical Name: 1-[6-bromo-3-fluoro-4-(triethylsilyl)-2-pyridinyl]Ethanone
• CAS No.: 1387561-10-5
• Molecular Formula: C₁₃H₁₉BrFNOSi
• Molecular Weight: 332.288
• Mol file: 1387561-10-5.mol

Synonyms:1-[6-bromo-3-fluoro-4-(triethylsilyl)-2-pyridinyl]Ethanone;1-(6-bromo-3-fluoro-4-triethylsilanyl-pyridin-2-yl)-ethanone

Chemical Property of 1-[6-bromo-3-fluoro-4-(triethylsilyl)-2-pyridinyl]Ethanone

Chemical Property:

• PSA: 29.96000
• LogP: 3.90130

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[6-bromo-3-fluoro-4-(triethylsilyl)-2-pyridinyl]Ethanone

There total 8 articles about 1-[6-bromo-3-fluoro-4-(triethylsilyl)-2-pyridinyl]Ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ISOPROPYLAMIDE (563-83-7) + 2-bromo-5-fluoro-4-triethylsilanylpyridine (1387561-09-2) → 1-(6-bromo-3-fluoro-4-(triethylsilyl)pyridin-2-yl)ethan-1-one (1387561-10-5)

Guidance literature:

2-bromo-5-fluoro-4-triethylsilanylpyridine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - -50 ℃; for 1.16667h;

ISOPROPYLAMIDE; In tetrahydrofuran; hexane; at -78 - -40 ℃; for 0.25h; Concentration; Time;

Reference yield: 91.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + 2-bromo-5-fluoro-4-triethylsilanylpyridine (1387561-09-2) → 1-(6-bromo-3-fluoro-4-(triethylsilyl)pyridin-2-yl)ethan-1-one (1387561-10-5)

Guidance literature:

2-bromo-5-fluoro-4-triethylsilanylpyridine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -75 ℃; for 1.16667h; Inert atmosphere;

N,N-dimethyl acetamide; In tetrahydrofuran; hexane; at -57 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c01300

Reference yield: 89.0%

2-bromo-5-fluoro-4-triethylsilanylpyridine (1387561-09-2) + N-Methoxy-N-methylacetamide (78191-00-1) → 1-(6-bromo-3-fluoro-4-(triethylsilyl)pyridin-2-yl)ethan-1-one (1387561-10-5)

Guidance literature:

2-bromo-5-fluoro-4-triethylsilanylpyridine; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 1.75h; Inert atmosphere;

N-Methoxy-N-methylacetamide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 1.16667h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c01518

upstream raw materials:

triethylsilyl chloride

2-bromo-5-fluoropyridine

N,N-dimethyl acetamide

2-bromo-5-fluoro-4-triethylsilanylpyridine

Downstream raw materials:

(R)-N-(2-(6-bromo-3-fluoro-4-(triethylsilyl)pyridin-2-yl)-2-hydroxypropyl)-4-nitrobenzenesulfonamide

6-bromo-3-fluoro-2-[(2S)-2-methyl-1-(4-nitrobenzenesulfonyl)aziridin-2-yl]-4-triethylsilanylpyridine

6-bromo-3-fluoro-2-[(2S)-2-methyl-1-(4-nitrobenzenesulfonyl)aziridin-2-yl]pyridine

(R)-2-[(R)-2-(6-bromo-3-fluoropyridin-2-yl)-2-(4-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide