METHYL 5-AMINO-2,4-DIMETHYLBENZOATE

Base Information

• Chemical Name: METHYL 5-AMINO-2,4-DIMETHYLBENZOATE
• CAS No.: 140112-97-6
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Hs Code.: 2922499990
• Mol file: 140112-97-6.mol

Synonyms:METHYL 5-AMINO-2,4-DIMETHYLBENZOATE;Benzoic acid, 5-amino-2,4-dimethyl-, methyl ester;5-Amino-2,4-dimethylbenzoic acid methyl ester

Chemical Property of METHYL 5-AMINO-2,4-DIMETHYLBENZOATE

Chemical Property:

• Refractive Index: 1.553
• Boiling Point: 300.812 °C at 760 mmHg
• PKA: 3.74±0.10(Predicted)
• Flash Point: 156.201 °C
• PSA: 52.32000
• Density: 1.105 g/cm³
• LogP: 2.25340
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

Methyl5-amino-2,4-dimethylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 5-AMINO-2,4-DIMETHYLBENZOATE

There total 4 articles about METHYL 5-AMINO-2,4-DIMETHYLBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 2,4-dimethyl-5-nitrobenzoate (202264-66-2) → methyl 5-amino-2,4-dimethylbenzoate (140112-97-6)

Guidance literature:

With cyclohexene; palladium on activated charcoal; In ethanol; for 16h; Heating;

DOI:10.1021/jo980564+

Reference yield:

2,4-dimethyl-benzoic acid methyl ester (23617-71-2) → methyl 5-amino-2,4-dimethylbenzoate (140112-97-6)

Guidance literature:

2,4-dimethyl-benzoic acid methyl ester; With sulfuric acid; nitric acid; In water; for 0.833333h; Cooling;

With hydrogen; palladium on activated carbon; In methanol; for 1h; under 2585.81 Torr;

Reference yield:

2,4-dimethyl-5-nitrobenzoic acid (220504-75-6) → methyl 5-amino-2,4-dimethylbenzoate (140112-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / conc. H₂SO₄ / Heating; overnight

2: 85 percent / cyclohexene / Pd-C / ethanol / 16 h / Heating

With sulfuric acid; cyclohexene; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo980564+

upstream raw materials:

methyl 2,4-dimethyl-5-nitrobenzoate

2,4-dimethyl-5-nitrobenzoic acid

2,4-dimethyl-benzoic acid

2,4-dimethyl-benzoic acid methyl ester

Downstream raw materials:

methyl 2,4-dimethyl-5-hydroxybenzene-1-carboxylate

methyl 2,4-dimethyl-5-acetoxybenzoate

methyl 2,4-bis-(bromomethyl)-5-acetoxybenzoate

3,4-dihydro-3-(phenylacetamido)-2,5-dihydro-2-oxofuro<3,4-d>-2H-1-benzopyran-2-one

Refernces

• 1、 -. "PHENYL mTORC INHIBITORS AND USES THEREOF". Paragraph 00313. . Retrieved 2018/05/27.
• 2、 -. "NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS". Page/Page column 78-79. . Retrieved 2010/05/13.