4-Bromo-2-chloro-1-(trifluoromethoxy)benzene

Base Information

• Chemical Name: 4-Bromo-2-chloro-1-(trifluoromethoxy)benzene
• CAS No.: 158579-80-7
• Molecular Formula: C₇H₃BrClF₃O
• Molecular Weight: 275.452
• Hs Code.: 2909309090
• Mol file: 158579-80-7.mol

Synonyms:4-Bromo-2-chloro-1-(trifluoromethoxy)benzene;

Chemical Property of 4-Bromo-2-chloro-1-(trifluoromethoxy)benzene

Chemical Property:

• Vapor Pressure: 0.403mmHg at 25°C
• Refractive Index: 1.493
• Boiling Point: 203.1 °C at 760 mmHg
• Flash Point: 76.6 °C
• PSA: 9.23000
• Density: 1.743 g/cm³
• LogP: 4.00110
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2-chloro-1-(trifluoromethoxy)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2-chloro-1-(trifluoromethoxy)benzene

There total 2 articles about 4-Bromo-2-chloro-1-(trifluoromethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

3-chloro-4-trifluoromethoxy-aniline (64628-73-5) → 4-bromo-2-chloro-1-trifluoromethoxybenzene (158579-80-7)

Guidance literature:

3-chloro-4-trifluoromethoxy-aniline; With hydrogen bromide; sodium nitrite; In water; at 0 - 5 ℃; for 1.75h; Inert atmosphere;

With urea; In water; for 0.333333h; Inert atmosphere;

With copper(I) bromide; In water; at 0 - 85 ℃; for 2.5h; Inert atmosphere;

Reference yield:

3-chloro-4-trifluoromethoxy-aniline (64628-73-5) + copper(I) bromide (7787-70-4) → 4-bromo-2-chloro-1-trifluoromethoxybenzene (158579-80-7) + 1-bromo-2-nitro-4-(trifluoromethoxy)benzene (95668-21-6)

Guidance literature:

With hydrogen bromide; sodium nitrite; In sulfuric acid; water; acetic acid;

Reference yield: 59.0%

4-bromo-2-chloro-1-trifluoromethoxybenzene (158579-80-7) + (4aS,8aS)-2,2-dimethyldecahydroquinoxaline (1365793-77-6) → (4aS,8aS)-1-(3-chloro-4-trifluoromethoxyphenyl)-3,3-dimethyldecahydroquinoxaline dihydrochloride

Guidance literature:

4-bromo-2-chloro-1-trifluoromethoxybenzene; (4aS,8aS)-2,2-dimethyldecahydroquinoxaline; With palladium diacetate; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate; In toluene; at 100 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; In ethanol; ethyl acetate; at 20 ℃;

upstream raw materials:

3-chloro-4-trifluoromethoxy-aniline

copper(I) bromide

Downstream raw materials:

(3-chloro-4-(trifluoromethoxy)phenyl)boronic acid

Refernces

• 1、 -. "4-benzoyl isoxazoles derivatives and their use as herbicides". . . Retrieved 2008/06/13.