(2R,4S)-4-(Methanesulfonyl-pyridin-3-ylmethyl-amino)-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2R,4S)-4-(Methanesulfonyl-pyridin-3-ylmethyl-amino)-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester
CAS No.:204072-75-3
Molecular Formula:C₂₀H₂₅N₃O₇S₂
Molecular Weight:483.566
Hs Code.:

Synonyms:(2R,4S)-4-(Methanesulfonyl-pyridin-3-ylmethyl-amino)-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

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Chemical Property of (2R,4S)-4-(Methanesulfonyl-pyridin-3-ylmethyl-amino)-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

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Technology Process of (2R,4S)-4-(Methanesulfonyl-pyridin-3-ylmethyl-amino)-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

There total 8 articles about (2R,4S)-4-(Methanesulfonyl-pyridin-3-ylmethyl-amino)-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 204072-75-3
(2R,4S)-4-(Methanesulfonyl-pyridin-3-ylmethyl-amino)-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N; DMAP / H₂O; dioxane / 14 h / 20 °C

2: SOCl₂ / 14 h

3: Et₃N / CH₂Cl₂ / 20 °C

4: 79 percent / NaN₃ / dimethylformamide / 26 h / 55 °C

5: 58 percent / H₂; HCOOH / 10percent Pd/C / ethanol; tetrahydrofuran / 16 h / 2792.67 Torr

6: NaCNBH₃; AcONa; AcOH / methanol / 48 h

7: Et₃N / CH₂Cl₂ / 2 h

With dmap; formic acid; thionyl chloride; sodium azide; hydrogen; sodium acetate; sodium cyanoborohydride; acetic acid; triethylamine; 10percent Pd/C; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm000246e

Reference yield:

: 2584-71-6,30724-02-8
cis-hydroxy-D-proline

: 204072-75-3
(2R,4S)-4-(Methanesulfonyl-pyridin-3-ylmethyl-amino)-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N; DMAP / H₂O; dioxane / 14 h / 20 °C

2: SOCl₂ / 14 h

3: Et₃N / CH₂Cl₂ / 20 °C

4: 79 percent / NaN₃ / dimethylformamide / 26 h / 55 °C

5: 58 percent / H₂; HCOOH / 10percent Pd/C / ethanol; tetrahydrofuran / 16 h / 2792.67 Torr

6: NaCNBH₃; AcONa; AcOH / methanol / 48 h

7: Et₃N / CH₂Cl₂ / 2 h

With dmap; formic acid; thionyl chloride; sodium azide; hydrogen; sodium acetate; sodium cyanoborohydride; acetic acid; triethylamine; 10percent Pd/C; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm000246e

Reference yield:

: 203994-66-5
(2R,4R)-4-Hydroxy-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid

: 204072-75-3
(2R,4S)-4-(Methanesulfonyl-pyridin-3-ylmethyl-amino)-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / 14 h

2: Et₃N / CH₂Cl₂ / 20 °C

3: 79 percent / NaN₃ / dimethylformamide / 26 h / 55 °C

4: 58 percent / H₂; HCOOH / 10percent Pd/C / ethanol; tetrahydrofuran / 16 h / 2792.67 Torr

5: NaCNBH₃; AcONa; AcOH / methanol / 48 h

6: Et₃N / CH₂Cl₂ / 2 h

With formic acid; thionyl chloride; sodium azide; hydrogen; sodium acetate; sodium cyanoborohydride; acetic acid; triethylamine; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000246e