Technology Process of 8-((3-((tert-butyldimethylsilyl)oxy)propyl)amino)-6-chloro-2-(3-methoxy-2-nitrophenyl)-4H-chromen-4-one
There total 5 articles about 8-((3-((tert-butyldimethylsilyl)oxy)propyl)amino)-6-chloro-2-(3-methoxy-2-nitrophenyl)-4H-chromen-4-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl;
In
tetrahydrofuran;
at 80 ℃;
regioselective reaction;
Inert atmosphere;
DOI:10.1016/j.ejmech.2014.07.018
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine / toluene / 2.5 h / 20 °C / Cooling with ice
2: potassium hydroxide / pyridine / 0.5 h / 100 °C / Microwave irradiation
3: sulfuric acid / ethanol / 0.5 h / 100 °C / Microwave irradiation
4: tris-(dibenzylideneacetone)dipalladium(0); (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; caesium carbonate / tetrahydrofuran / 80 °C / Inert atmosphere
With
pyridine; tris-(dibenzylideneacetone)dipalladium(0); sulfuric acid; caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; potassium hydroxide;
In
tetrahydrofuran; pyridine; ethanol; toluene;
4: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.ejmech.2014.07.018
- Guidance literature:
-
Multi-step reaction with 5 steps
1: thionyl chloride / toluene / 20 h / Reflux
2: pyridine / toluene / 2.5 h / 20 °C / Cooling with ice
3: potassium hydroxide / pyridine / 0.5 h / 100 °C / Microwave irradiation
4: sulfuric acid / ethanol / 0.5 h / 100 °C / Microwave irradiation
5: tris-(dibenzylideneacetone)dipalladium(0); (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; caesium carbonate / tetrahydrofuran / 80 °C / Inert atmosphere
With
pyridine; tris-(dibenzylideneacetone)dipalladium(0); thionyl chloride; sulfuric acid; caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; potassium hydroxide;
In
tetrahydrofuran; pyridine; ethanol; toluene;
5: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.ejmech.2014.07.018
