N-(4-chloro-2-iodiphenyl)-N-methylcinnamide

Base Information

• Chemical Name: N-(4-chloro-2-iodiphenyl)-N-methylcinnamide
• CAS No.: 252556-97-1
• Molecular Formula: C₁₆H₁₃ClINO
• Molecular Weight: 397.643
• Mol file: 252556-97-1.mol

Synonyms:N-(4-chloro-2-iodiphenyl)-N-methylcinnamide

Chemical Property of N-(4-chloro-2-iodiphenyl)-N-methylcinnamide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-chloro-2-iodiphenyl)-N-methylcinnamide

There total 7 articles about N-(4-chloro-2-iodiphenyl)-N-methylcinnamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-chloro-2-iodiphenyl)cinnamide → N-(4-chloro-2-iodiphenyl)-N-methylcinnamide (252556-97-1)

Guidance literature:

N-(4-chloro-2-iodiphenyl)cinnamide; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

methyl halide; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

DOI:10.1039/c7ob02585h

Reference yield:

N-(4-chloro-2-iodiphenyl)cinnamide + methyl iodide (74-88-4) → N-(4-chloro-2-iodiphenyl)-N-methylcinnamide (252556-97-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1107/S010827019900791X

Reference yield:

Cinnamoyl chloride (102-92-1,17082-09-6) → N-(4-chloro-2-iodiphenyl)-N-methylcinnamide (252556-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 5 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

2.2: 12 h / 0 - 20 °C

With dmap; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c7ob02585h

upstream raw materials:

methyl iodide

p-chloro-o-iodoaniline

Cinnamoyl chloride

(E)-3-phenylacrylic acid