(R)-(4-(4-chlorophthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone

Base Information

• Chemical Name: (R)-(4-(4-chlorophthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
• CAS No.: 1095639-04-5
• Molecular Formula: C₂₀H₁₉ClN₄O
• Molecular Weight: 366.85

Synonyms:(R)-(4-(4-chlorophthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone

Chemical Property of (R)-(4-(4-chlorophthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone

Chemical Property:

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Technology Process of (R)-(4-(4-chlorophthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone

There total 1 articles about (R)-(4-(4-chlorophthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-chloro-4-(2-methylpiperazin-1-yl)phthalazine (1095639-01-2) + benzoyl chloride (98-88-4) → (R)-(4-(4-chlorophthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone (1095639-04-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 86.0%

(R)-(4-(4-chlorophthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone (1095639-04-5) + 4-methylphenylboronic acid (5720-05-8) → (R)-(3-methyl-4-(4-p-tolylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone (1095637-80-1)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 100 ℃; Heating / reflux;

Reference yield: 25.0%

(R)-(4-(4-chlorophthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone (1095639-04-5) + 2-(tributyltin)oxazole (145214-05-7) → C23H21N5O2 (1245773-23-2)

Guidance literature:

With bis(tri-tert-butylphosphine)palladium; cesium fluoride; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2010.06.006

upstream raw materials:

(R)-1-chloro-4-(2-methylpiperazin-1-yl)phthalazine

benzoyl chloride

Downstream raw materials:

(R)-(3-methyl-4-(4-p-tolylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone

(R)-(3-methyl-4-(4-morpholinophthalazin-1-yl)piperazin-1-yl)(phenyl)methanone

(R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone

((R)-3-methyl-4-(4-(pyridin-2-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone

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