7α-benzyloxymethyl-6α-hydroxy-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Base Information

Chemical Name:7α-benzyloxymethyl-6α-hydroxy-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole
CAS No.:142502-22-5
Molecular Formula:C₃₂H₃₃NO₄S
Molecular Weight:527.684
Hs Code.:

Synonyms:7α-benzyloxymethyl-6α-hydroxy-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

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Chemical Property of 7α-benzyloxymethyl-6α-hydroxy-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

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Technology Process of 7α-benzyloxymethyl-6α-hydroxy-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

There total 4 articles about 7α-benzyloxymethyl-6α-hydroxy-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 100-39-0
benzyl bromide

: 142502-21-4
6α-hydroxy-7α-hydroxymethyl-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

: 142502-22-5
7α-benzyloxymethyl-6α-hydroxy-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In benzene; for 0.5h; Ambient temperature;
DOI:10.1016/0223-5234(92)90100-F

Reference yield:

: 142502-20-3
7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole-7α,6α-carbolactone

: 142502-22-5
7α-benzyloxymethyl-6α-hydroxy-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

2: 87 percent / n-Bu₄NHSO₄, 50percent NaOH / benzene / 0.5 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; benzene;
DOI:10.1016/0223-5234(92)90100-F

Reference yield:

: 142502-19-0
9-methyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole-7α,6α-carbolactone

: 142502-22-5
7α-benzyloxymethyl-6α-hydroxy-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, RT, 2 h

2: 45 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

3: 87 percent / n-Bu₄NHSO₄, 50percent NaOH / benzene / 0.5 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; tetra(n-butyl)ammonium hydrogensulfate; lithium diisopropyl amide; In tetrahydrofuran; benzene;
DOI:10.1016/0223-5234(92)90100-F