(R)-3-[(2R,3S,4S)-3,5-dihydroxy-2,4-dimethylpentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

Base Information

Chemical Name:(R)-3-[(2R,3S,4S)-3,5-dihydroxy-2,4-dimethylpentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one
CAS No.:443761-69-1
Molecular Formula:C₂₅H₃₁NO₅
Molecular Weight:425.525
Hs Code.:

Synonyms:(R)-3-[(2R,3S,4S)-3,5-dihydroxy-2,4-dimethylpentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

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Chemical Property of (R)-3-[(2R,3S,4S)-3,5-dihydroxy-2,4-dimethylpentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

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Technology Process of (R)-3-[(2R,3S,4S)-3,5-dihydroxy-2,4-dimethylpentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

There total 2 articles about (R)-3-[(2R,3S,4S)-3,5-dihydroxy-2,4-dimethylpentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 443761-79-3
(R)-3-[(2R,3R)-3-hydroxy-2,4-dimethylpent-4-enoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

: 443761-69-1
(R)-3-[(2R,3S,4S)-3,5-dihydroxy-2,4-dimethylpentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

Guidance literature:: (R)-3-[(2R,3R)-3-hydroxy-2,4-dimethylpent-4-enoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one; With Thexylboran; In tetrahydrofuran; at 0 ℃; for 2.66667h; Inert atmosphere;

With dihydrogen peroxide; In tetrahydrofuran; aq. phosphate buffer; ethanol; at 0 - 23 ℃; for 16h; pH=7; Inert atmosphere;
DOI:10.1021/op049950l

Reference yield:

: 223906-53-4
(4R)-N-Propionyl-5,5-diphenyl-4-isopropyloxazolidin-2-one

: 443761-69-1
(R)-3-[(2R,3S,4S)-3,5-dihydroxy-2,4-dimethylpentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: di-n-butylboryl trifluoromethanesulfonate; triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

1.2: 2 h / -78 - -45 °C / Inert atmosphere

2.1: Thexylboran / tetrahydrofuran / 2.67 h / 0 °C / Inert atmosphere

2.2: 16 h / 0 - 23 °C / pH 7 / Inert atmosphere

With Thexylboran; di-n-butylboryl trifluoromethanesulfonate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/op049950l