(R)-3-[(2R,3S,4S)-2,4-dimethyl-3,5-bis(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

Base Information

• Chemical Name: (R)-3-[(2R,3S,4S)-2,4-dimethyl-3,5-bis(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one
• CAS No.: 649755-75-9
• Molecular Formula: C₃₇H₅₉NO₅Si₂
• Molecular Weight: 654.05

Synonyms:(R)-3-[(2R,3S,4S)-2,4-dimethyl-3,5-bis(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

Chemical Property of (R)-3-[(2R,3S,4S)-2,4-dimethyl-3,5-bis(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

Chemical Property:

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Technology Process of (R)-3-[(2R,3S,4S)-2,4-dimethyl-3,5-bis(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

There total 2 articles about (R)-3-[(2R,3S,4S)-2,4-dimethyl-3,5-bis(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-[(2R,3S,4S)-3,5-dihydroxy-2,4-dimethylpentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one (443761-69-1) + t-butyldimethylsiyl triflate (69739-34-0) → (R)-3-[(2R,3S,4S)-2,4-dimethyl-3,5-bis(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one (649755-75-9)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at -78 - 0 ℃; for 3.08333h;

Reference yield:

(R)-3-[(2R,3S,4S)-3,5-dihydroxy-2,4-dimethylpentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one (443761-69-1) + triethylsilyl chloride (994-30-9) → (R)-3-[(2R,3S,4S)-2,4-dimethyl-3,5-bis(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one (649755-75-9)

Guidance literature:

With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 40 ℃; for 2h; Inert atmosphere;

DOI:10.1021/op049950l

Reference yield:

(R)-3-[(2R,3S,4S)-2,4-dimethyl-3,5-bis(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one (649755-75-9) → (R)-3-[(2R,3S,4S)-5-hydroxy-2,4-dimethyl-3-(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one (649755-76-0)

Guidance literature:

With acetic acid; In tetrahydrofuran; methanol; water; at 23 - 50 ℃; for 5h; Heating / reflux;

upstream raw materials:

(R)-3-[(2R,3S,4S)-3,5-dihydroxy-2,4-dimethylpentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

t-butyldimethylsiyl triflate

triethylsilyl chloride

Downstream raw materials:

(R)-3-[(2R,3S,4S)-5-hydroxy-2,4-dimethyl-3-(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

(3R,4S,5S)-3,5-dimethyl-4-[(triethylsilanyl)oxy]tetrahydropyran-2-one

(R)-4-(1-methylethyl)-5,5-diphenyl-1,3-oxazolidin-2-one

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