Ethyl 2-(2,3-dichlorophenoxy)acetate

Base Information

• Chemical Name: Ethyl 2-(2,3-dichlorophenoxy)acetate
• CAS No.: 37536-92-8
• Molecular Formula: C₁₀H₁₀Cl₂O₃
• Molecular Weight: 249.094
• European Community (EC) Number: 652-159-6
• Nikkaji Number: J1.369.118E
• Mol file: 37536-92-8.mol

Synonyms:Ethyl 2-(2,3-dichlorophenoxy)acetate;37536-92-8;ethyl (2,3-dichlorophenoxy)acetate;Ethyl2-(2,3-dichlorophenoxy)acetate;STK441824;AKOS003312464;Ethyl 2-(2,3-dichloro-phenoxy)acetate;CS-0361367;(2,3-Dichlorophenoxy)acetic acid ethyl ester

Chemical Property of Ethyl 2-(2,3-dichlorophenoxy)acetate

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 248.0006996
• Heavy Atom Count: 15
• Complexity: 211

Purity/Quality:

95% ^*data from raw suppliers

ETHYL 2-(2,3-DICHLOROPHENOXY)ACETATE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)COC1=C(C(=CC=C1)Cl)Cl

Technology Process of Ethyl 2-(2,3-dichlorophenoxy)acetate

There total 3 articles about Ethyl 2-(2,3-dichlorophenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

ethyl 2-hydroxyacetate (623-50-7) + 1,2,3-trichlorobenzene (87-61-6) → (dichloro-2,3 phenoxy)acetate d'ethyle (37536-92-8)

Guidance literature:

ethyl 2-hydroxyacetate; With potassium methanolate; at 30 ℃;

1,2,3-trichlorobenzene; at 100 ℃;

Reference yield: 98.0%

2,3-dichlorophenol (576-24-9) + ethyl bromoacetate (105-36-2) → (dichloro-2,3 phenoxy)acetate d'ethyle (37536-92-8)

Guidance literature:

With potassium carbonate; In acetone; at 50 ℃; for 3h;

DOI:10.1021/acs.molpharmaceut.8b00250

Reference yield:

→ (dichloro-2,3 phenoxy)acetate d'ethyle (37536-92-8)

Guidance literature:

s.a.Beisp. 3b;

upstream raw materials:

2,3-dichlorophenol

ethyl bromoacetate

ethyl 2-hydroxyacetate

1,2,3-trichlorobenzene

Downstream raw materials:

2,3-dichlorophenoxyacetic acid

bromure de benzoyl methylthio-2 thiopyrylium

-4 phenoxy>acetate d'ethyle

acide-4 phenoxy>-acetique

Refernces

• 1、 Alnouti, Yazen,Aretz, Christopher D.,Chhonker, Yashpal S.,Dhuria, Nikilesh V.,Du, Yu,Gautam, Nagsen,Hopkins, Corey R.,Kumar, Sushil,Lesiak, Lauren,Sharma, Swagat,Weaver, C. David. "Discovery, synthesis and biological characterization of a series of: N -(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1 H -pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators". supporting information. p. 1366 - 1373. Retrieved 2021/09/28.
• 2、 -. "Preparation method of chlorophenoxyacetic ester". Paragraph 0064; 0066. . Retrieved 2019/01/08.