[2-(6-amino-purin-9-yl)-ethoxymethyl]-phosphonic acid mono-{2-[2-(3-chloro-phenyl)-[1,3]dioxolan-2-yl]-ethyl} ester

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Chemical Name:[2-(6-amino-purin-9-yl)-ethoxymethyl]-phosphonic acid mono-{2-[2-(3-chloro-phenyl)-[1,3]dioxolan-2-yl]-ethyl} ester
CAS No.:805232-93-3
Molecular Formula:C₁₉H₂₃ClN₅O₆P
Molecular Weight:483.848
Hs Code.:

Synonyms:[2-(6-amino-purin-9-yl)-ethoxymethyl]-phosphonic acid mono-{2-[2-(3-chloro-phenyl)-[1,3]dioxolan-2-yl]-ethyl} ester

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Chemical Property of [2-(6-amino-purin-9-yl)-ethoxymethyl]-phosphonic acid mono-{2-[2-(3-chloro-phenyl)-[1,3]dioxolan-2-yl]-ethyl} ester

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Technology Process of [2-(6-amino-purin-9-yl)-ethoxymethyl]-phosphonic acid mono-{2-[2-(3-chloro-phenyl)-[1,3]dioxolan-2-yl]-ethyl} ester

There total 2 articles about [2-(6-amino-purin-9-yl)-ethoxymethyl]-phosphonic acid mono-{2-[2-(3-chloro-phenyl)-[1,3]dioxolan-2-yl]-ethyl} ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 807361-75-7
9-bis-{2-[1-{(3-chlorophenyl)-3-[1,3]dioxolanyl-1-propyl}phosphonomethoxy]ethyl}-6-(dimethylaminomethyleneimino)adenine

: 805232-93-3
[2-(6-amino-purin-9-yl)-ethoxymethyl]-phosphonic acid mono-{2-[2-(3-chloro-phenyl)-[1,3]dioxolan-2-yl]-ethyl} ester

Guidance literature:: With lithium hydroxide; In acetonitrile; Heating;
DOI:10.1021/ja031818y

Reference yield:

: 1037071-06-9
C₁₁H₁₅Cl₂N₆O₂P

: 805232-93-3
[2-(6-amino-purin-9-yl)-ethoxymethyl]-phosphonic acid mono-{2-[2-(3-chloro-phenyl)-[1,3]dioxolan-2-yl]-ethyl} ester

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / triethylamine / CH₂Cl₂ / 20 °C

2: aq. LiOH / acetonitrile / Heating

With lithium hydroxide; triethylamine; In dichloromethane; acetonitrile; 1: Swern oxidation;
DOI:10.1021/ja031818y