9-bis-{2-[1-{(3-chlorophenyl)-3-[1,3]dioxolanyl-1-propyl}phosphonomethoxy]ethyl}-6-(dimethylaminomethyleneimino)adenine

Base Information

Chemical Name:9-bis-{2-[1-{(3-chlorophenyl)-3-[1,3]dioxolanyl-1-propyl}phosphonomethoxy]ethyl}-6-(dimethylaminomethyleneimino)adenine
CAS No.:807361-75-7
Molecular Formula:C₃₃H₃₉Cl₂N₆O₈P
Molecular Weight:749.588
Hs Code.:

Synonyms:9-bis-{2-[1-{(3-chlorophenyl)-3-[1,3]dioxolanyl-1-propyl}phosphonomethoxy]ethyl}-6-(dimethylaminomethyleneimino)adenine

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Chemical Property of 9-bis-{2-[1-{(3-chlorophenyl)-3-[1,3]dioxolanyl-1-propyl}phosphonomethoxy]ethyl}-6-(dimethylaminomethyleneimino)adenine

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Technology Process of 9-bis-{2-[1-{(3-chlorophenyl)-3-[1,3]dioxolanyl-1-propyl}phosphonomethoxy]ethyl}-6-(dimethylaminomethyleneimino)adenine

There total 3 articles about 9-bis-{2-[1-{(3-chlorophenyl)-3-[1,3]dioxolanyl-1-propyl}phosphonomethoxy]ethyl}-6-(dimethylaminomethyleneimino)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 805231-26-9
2-[2-(3-chlorophenyl)-[1,3]dioxolan-2-yl]ethanol

: 1037071-06-9
C₁₁H₁₅Cl₂N₆O₂P

: 807361-75-7
9-bis-{2-[1-{(3-chlorophenyl)-3-[1,3]dioxolanyl-1-propyl}phosphonomethoxy]ethyl}-6-(dimethylaminomethyleneimino)adenine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/ja031818y

Reference yield:

: 805231-20-3
[2-(3-chlorophenyl)-[1,3]dioxolan-2-yl]acetic acid ethyl ester

: 807361-75-7
9-bis-{2-[1-{(3-chlorophenyl)-3-[1,3]dioxolanyl-1-propyl}phosphonomethoxy]ethyl}-6-(dimethylaminomethyleneimino)adenine

Guidance literature:: Multi-step reaction with 2 steps

1: 367 mg / LiAlH₄ / tetrahydrofuran / 48 h / 20 °C

2: 59 percent / triethylamine / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane; 2: Swern oxidation;
DOI:10.1021/ja031818y

Reference yield:

: 33167-21-4
3-(3-chloro-phenyl)-3-oxo-propionic acid ethyl ester

: 807361-75-7
9-bis-{2-[1-{(3-chlorophenyl)-3-[1,3]dioxolanyl-1-propyl}phosphonomethoxy]ethyl}-6-(dimethylaminomethyleneimino)adenine

Guidance literature:: Multi-step reaction with 3 steps

1: p-TsOH / benzene / 24 h / Heating

2: 367 mg / LiAlH₄ / tetrahydrofuran / 48 h / 20 °C

3: 59 percent / triethylamine / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; benzene; 3: Swern oxidation;
DOI:10.1021/ja031818y