3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole

Base Information

Chemical Name:3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole
CAS No.:1262193-44-1
Molecular Formula:C₂₁H₁₈F₃N₅O
Molecular Weight:413.402
Hs Code.:

Synonyms:3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole

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Chemical Property of 3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole

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Technology Process of 3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole

There total 3 articles about 3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1262193-43-0
3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole

: 74-88-4
methyl iodide

: 1262193-44-1
3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole

: 1262193-45-2
5-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-3-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h; Cooling with ice; Inert atmosphere;

Reference yield:

: 1262197-07-8
C₁₄H₁₆N₂O₃

: 1262193-44-1
3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole

: 1262193-45-2
5-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-3-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 32 h / 130 °C / Autoclave; Inert atmosphere

2: potassium carbonate / ethanol / 12 h / 120 °C / Microwave irradiation

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Cooling with ice; Inert atmosphere

With sodium hydride; potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 368-77-4
3-trifluoromethylbenzonitrile

: 1242314-39-1
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzohydrazide

: 1262193-44-1
3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole

: 1262193-45-2
5-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-3-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / ethanol / 12 h / 120 °C / Microwave irradiation

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Cooling with ice; Inert atmosphere

With sodium hydride; potassium carbonate; In ethanol; N,N-dimethyl-formamide; mineral oil;