4-(2-(4-fluoro-3-(2-morpholinoacetamido)phenyl)thiazol-4-yl)-1H-pyrrole-2-carboxylic acid

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Chemical Name:4-(2-(4-fluoro-3-(2-morpholinoacetamido)phenyl)thiazol-4-yl)-1H-pyrrole-2-carboxylic acid
CAS No.:1415820-51-7
Molecular Formula:C₂₀H₁₉FN₄O₄S
Molecular Weight:430.46
Hs Code.:

Synonyms:4-(2-(4-fluoro-3-(2-morpholinoacetamido)phenyl)thiazol-4-yl)-1H-pyrrole-2-carboxylic acid

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Chemical Property of 4-(2-(4-fluoro-3-(2-morpholinoacetamido)phenyl)thiazol-4-yl)-1H-pyrrole-2-carboxylic acid

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Technology Process of 4-(2-(4-fluoro-3-(2-morpholinoacetamido)phenyl)thiazol-4-yl)-1H-pyrrole-2-carboxylic acid

There total 10 articles about 4-(2-(4-fluoro-3-(2-morpholinoacetamido)phenyl)thiazol-4-yl)-1H-pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415820-50-6
methyl 4-(2-(4-fluoro-3-(2-morpholinoacetamido)phenyl)thiazol-4-yl)-1H-pyrrole-2-carboxylate

: 1415820-51-7
4-(2-(4-fluoro-3-(2-morpholinoacetamido)phenyl)thiazol-4-yl)-1H-pyrrole-2-carboxylic acid

Guidance literature:: methyl 4-(2-(4-fluoro-3-(2-morpholinoacetamido)phenyl)thiazol-4-yl)-1H-pyrrole-2-carboxylate; With water; sodium hydroxide; In 1,4-dioxane; at 80 ℃; for 2h;

With hydrogenchloride; In water;

Reference yield:

: 400-94-2
4-fluoro-3-nitrobenzoyl chloride

: 1415820-51-7
4-(2-(4-fluoro-3-(2-morpholinoacetamido)phenyl)thiazol-4-yl)-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonia / toluene; methanol / 0.25 h / 20 °C

2.1: Lawessons reagent / 1,2-dimethoxyethane; tetrahydrofuran / 2 h / 50 °C

2.2: 1 h / 20 °C

3.1: acetic acid / 2 h / Reflux

4.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 72 h / Reflux

5.1: triethylamine / dichloromethane / 1 h / Cooling with ice

6.1: triethylamine / 1,4-dioxane / 2 h / Reflux

7.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 80 °C

With Lawessons reagent; ammonia; water; hydrogen; acetic acid; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; toluene;

Reference yield:

: 1193-62-0
methyl Pyrrole-2-carboxylate

: 1415820-51-7
4-(2-(4-fluoro-3-(2-morpholinoacetamido)phenyl)thiazol-4-yl)-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: aluminum (III) chloride / dichloromethane / Reflux

2: acetic acid / 2 h / Reflux

3: hydrogen / palladium on activated charcoal / tetrahydrofuran / 72 h / Reflux

4: triethylamine / dichloromethane / 1 h / Cooling with ice

5: triethylamine / 1,4-dioxane / 2 h / Reflux

6: sodium hydroxide; water / 1,4-dioxane / 2 h / 80 °C

With aluminum (III) chloride; water; hydrogen; acetic acid; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane;