(5R,7S)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

Base Information

Chemical Name:(5R,7S)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS No.:1403602-33-4
Molecular Formula:C₂₄H₂₃F₃N₄O₃
Molecular Weight:472.467
Hs Code.:

Synonyms:(5R,7S)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Property of (5R,7S)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

Chemical Property:

Boiling Point:660.7±55.0 °C(Predicted)
Density:1.45±0.1 g/cm3(Predicted)

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Technology Process of (5R,7S)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

There total 5 articles about (5R,7S)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.4%

: 2620-50-0
1,3-benzodioxol-5-ylmethyl amine

: 1403602-92-5
(5R,7S)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: 1403602-33-4
(5R,7S)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: (5R,7S)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

1,3-benzodioxol-5-ylmethyl amine; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

: 1495-03-0
1-(4-ethylphenyl)-4,4,4-trifluorobutane-1,3-dione

: 1403602-33-4
(5R,7S)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 6 h / Reflux

2.1: sodium tetrahydroborate / methanol / 5 h / 20 °C / Inert atmosphere

3.1: water; potassium hydroxide / ethanol / 12 h / 60 °C

4.1: Chiralpak IC / ethanol; n-heptane / Resolution of racemate

5.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 50 °C

With sodium tetrahydroborate; water; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In methanol; ethanol; n-heptane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1260243-05-7
ethyl 5-(4-ethylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

: 1403602-33-4
(5R,7S)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / methanol / 5 h / 20 °C / Inert atmosphere

2.1: water; potassium hydroxide / ethanol / 12 h / 60 °C

3.1: Chiralpak IC / ethanol; n-heptane / Resolution of racemate

4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 50 °C

With sodium tetrahydroborate; water; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In methanol; ethanol; n-heptane; N,N-dimethyl-formamide;