1495-03-0

Basic information

• Product Name: 1-(4-ETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE
• Synonyms: 1-(4-ETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE;AKOS B007347;ART-CHEM-BB B007347;VITAS-BB TBB006671;1-(4-Ethylphenyl)-4,4,4-trifluoro-1,3-butanedione
• CAS NO: 1495-03-0
• Molecular Formula: C₁₂H₁₁F₃O₂
• Molecular Weight: 244.21
• Mol File: 1495-03-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-ETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-ETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE(1495-03-0)
• EPA Substance Registry System: 1-(4-ETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE(1495-03-0)

Safety Data

• Hazardous Substances Data: 1495-03-0(Hazardous Substances Data)

Usage

Description

1-(4-ETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE, also known as EFIB, is a chemical compound with the molecular formula C13H14F3O2. It is a yellow solid with a melting point of 48-51°C and a boiling point of 94-96°C. EFIB is known for its strong odour and is considered to be a potential respiratory irritant.
Used in Pharmaceutical Industry:
1-(4-ETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE is used as an intermediate in the synthesis of pharmaceuticals for its versatile chemical properties.
Used in Agrochemical Industry:
1-(4-ETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE is used as an intermediate in the synthesis of agrochemicals for its ability to contribute to the development of effective compounds.
Used in Organic Compounds Production:
1-(4-ETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE is used as a building block for the production of organic compounds due to its unique structure and properties.
Used in Dyes and Pigments Industry:
1-(4-ETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE is used as a building block for the production of dyes and pigments, contributing to the creation of specialty chemicals.
Used in Specialty Chemicals Production:
1-(4-ETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE is used as a building block for the production of specialty chemicals, highlighting its wide range of applications in the chemical industry.

Upstream product

• 937-30-4 4-ethylacetophenone 
• 383-63-1 ethyl trifluoroacetate, 

Downstream Products

• 1403602-92-5 (5R,7S)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid 
• 1403602-59-4 (5R,7S)-5-(4-ethylphenyl)-N-(4-methoxybenzyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1403602-60-7 (5S,7R)-5-(4-ethylphenyl)-N-(4-methoxybenzyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1403602-33-4 (5R,7S)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1442648-47-6 2-(β-D-ribofuranosyl)-4-(4-ethylphenyl)-6-(trifluoromethyl)pyrimidine 
• 1260243-05-7 ethyl 5-(4-ethylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate 

Relevant articles and documents

Synthesis, fungicidal activity and mode of action of 4-phenyl-6-trifluoromethyl-2-aminopyrimidines against Botrytis cinerea

Anilinopyrimidines are the main chemical agents for management of Botrytis cinerea. However, the drug resistance in fungi against this kind of compounds is very serious. To explore new potential fungicides against B. cinerea, a series of 4-phenyl-6-trifluoromethyl-2-amino-pyrimidine compounds (compounds III-1 to III-22) were synthesized, and their structures were confirmed by 1H-NMR, IR and MS. Most of these compounds possessed excellent fungicidal activity. The compounds III-3 and III-13 showed higher fungicidal activity than the positive control pyrimethanil on fructose gelatin agar (FGA), and compound III-3 on potato dextrose agar (PDA) indicated high activity compared to the positive control cyprodinil. In vivo greenhouse results indicated that the activity of compounds III-3, III-8, and III-11 was significantly higher than that of the fungicide pyrimethanil. Scanning electron micrography (SEM) and transmission electron micrography (TEM) were applied to illustrate the mechanism of title compounds against B. cinerea. The title compounds, especially those containing a fluorine atom at the ortho-position on the benzene ring, could maintain the antifungal activity against B. cinerea, but their mechanism of action is different from that of cyprodinil. The present study lays a good foundation for us to find more efficient reagents against B. cinerea.

New Heterocyclic compounds for therapeutic use

A class of compounds particularly diaryl pyrazole of general formulas 1 and 2 where R and R′ represents alkyl, hydrogen, halogens, haloalkyl, cyano, nitro, formyl, carboxyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, hydroxyalkyl, alkylthio, alkylsulfinyl, alkylsulphonyl, N- alkylsulfamyl, N-arylsulfamyl, cyanoamido, amino, amidino, N-monoalkylamido, N-monoarylamido, N,N-dialkylamido, N-alkyl-N-arylamido, N, N-dialkylsulfamyl with the alkyl, or alkyl part of each such group containing 1-3 carbon atoms or mixtures thereof optionally their salts when they exist, and preparation thereof. The compounds of the present invention are antiinflammatory, antipyretic, antirheumatic, antiosteoarthritic agents with antibacterial activity. The particular class of compounds is given below (Formula 1 and Formula 2).