chloro-N-cyclohex-2-enylmethyl-[2-(3,4-dimethoxyphenyl)ethyl]acetamide

Base Information

• Chemical Name: chloro-N-cyclohex-2-enylmethyl-[2-(3,4-dimethoxyphenyl)ethyl]acetamide
• CAS No.: 370866-98-1
• Molecular Formula: C₁₉H₂₃ClN₂O
• Molecular Weight: 330.857
• Mol file: 370866-98-1.mol

Synonyms:chloro-N-cyclohex-2-enylmethyl-[2-(3,4-dimethoxyphenyl)ethyl]acetamide

Chemical Property of chloro-N-cyclohex-2-enylmethyl-[2-(3,4-dimethoxyphenyl)ethyl]acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of chloro-N-cyclohex-2-enylmethyl-[2-(3,4-dimethoxyphenyl)ethyl]acetamide

There total 3 articles about chloro-N-cyclohex-2-enylmethyl-[2-(3,4-dimethoxyphenyl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloroacetyl chloride (79-04-9) + cyclohex-2-enylmethyl-[2-(1H-indol-3-yl)-ethyl]-amine → chloro-N-cyclohex-2-enylmethyl-[2-(3,4-dimethoxyphenyl)ethyl]acetamide (370866-98-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/ol016424v

Reference yield:

tryptamine (61-54-1) → chloro-N-cyclohex-2-enylmethyl-[2-(3,4-dimethoxyphenyl)ethyl]acetamide (370866-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetonitrile / 72 h / Heating

2: 1.94 g / triethylamine / CH₂Cl₂ / 2 h / 20 °C

With potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/ol016424v

Reference yield:

(2-cyclohexenyl)methyl methanesulfonate (156731-33-8) → chloro-N-cyclohex-2-enylmethyl-[2-(3,4-dimethoxyphenyl)ethyl]acetamide (370866-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetonitrile / 72 h / Heating

2: 1.94 g / triethylamine / CH₂Cl₂ / 2 h / 20 °C

With potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/ol016424v

upstream raw materials:

chloroacetyl chloride

tryptamine

(2-cyclohexenyl)methyl methanesulfonate

Downstream raw materials:

dithiocarbonic acid S-(cyclohex-2-enylmethyl-N-[2-(1H-indol-3-yl)ethyl]-carbamoyl)methyl O-ethyl ester