trans-3-(1-hydroxyethyl)-4-(α-methylstyryl)-1-(4-methoxyphenyl)azetidin-2-one

Base Information

Chemical Name:trans-3-(1-hydroxyethyl)-4-(α-methylstyryl)-1-(4-methoxyphenyl)azetidin-2-one
CAS No.:100239-22-3
Molecular Formula:C₂₁H₂₃NO₃
Molecular Weight:337.419
Hs Code.:

Synonyms:trans-3-(1-hydroxyethyl)-4-(α-methylstyryl)-1-(4-methoxyphenyl)azetidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-3-(1-hydroxyethyl)-4-(α-methylstyryl)-1-(4-methoxyphenyl)azetidin-2-one

Chemical Property:

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Technology Process of trans-3-(1-hydroxyethyl)-4-(α-methylstyryl)-1-(4-methoxyphenyl)azetidin-2-one

There total 9 articles about trans-3-(1-hydroxyethyl)-4-(α-methylstyryl)-1-(4-methoxyphenyl)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 122673-11-4
1-(4-methoxyphenyl)-4-(α-methylstyryl)azetidin-2-one

: 75-07-0,9002-91-9
acetaldehyde

: 100239-22-3
trans-3-(1-hydroxyethyl)-4-(α-methylstyryl)-1-(4-methoxyphenyl)azetidin-2-one

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; from -78 deg C to r.t.;
DOI:10.1039/c39890000074

Reference yield: 35.0%

: 5405-41-4
ethyl 3-hydroxybutyrate

: 100239-15-4
(E)-4-methoxy-N-((E)-2-methyl-3-phenylallylidene)aniline

: 100239-22-3,100296-98-8,106399-78-4,106399-79-5,106399-80-8,122673-13-6,122673-15-8
3-(1-Hydroxy-ethyl)-1-(4-methoxy-phenyl)-4-((E)-1-methyl-2-phenyl-vinyl)-azetidin-2-one

Guidance literature:: With lithium cyclohexylisopropylamide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; the reaction mixture was quenched at room temp.;
DOI:10.1016/S0040-4039(00)98683-0

Reference yield:

: 100239-15-4
(E)-4-methoxy-N-((E)-2-methyl-3-phenylallylidene)aniline

: 100239-22-3
trans-3-(1-hydroxyethyl)-4-(α-methylstyryl)-1-(4-methoxyphenyl)azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Zn, ClSiMe₃ / benzene / 2.5 h / Heating

2: 98 percent / 1.) LDA / tetrahydrofuran / from -78 deg C to r.t.

With chloro-trimethyl-silane; zinc; lithium diisopropyl amide; In tetrahydrofuran; benzene;
DOI:10.1039/c39890000074