5-[4,5-bis(methoxymethoxy)-2-methylphenyl]-7-methoxy-2,2-dimethyl-4H-1,3-benzodioxin-4-one

Base Information

Chemical Name:5-[4,5-bis(methoxymethoxy)-2-methylphenyl]-7-methoxy-2,2-dimethyl-4H-1,3-benzodioxin-4-one
CAS No.:709024-96-4
Molecular Formula:C₂₂H₂₆O₈
Molecular Weight:418.444
Hs Code.:

Synonyms:5-[4,5-bis(methoxymethoxy)-2-methylphenyl]-7-methoxy-2,2-dimethyl-4H-1,3-benzodioxin-4-one

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Chemical Property of 5-[4,5-bis(methoxymethoxy)-2-methylphenyl]-7-methoxy-2,2-dimethyl-4H-1,3-benzodioxin-4-one

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Technology Process of 5-[4,5-bis(methoxymethoxy)-2-methylphenyl]-7-methoxy-2,2-dimethyl-4H-1,3-benzodioxin-4-one

There total 6 articles about 5-[4,5-bis(methoxymethoxy)-2-methylphenyl]-7-methoxy-2,2-dimethyl-4H-1,3-benzodioxin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 532394-19-7
C₁₁H₁₇BO₆

: 532394-17-5
7-methoxy-2,2-dimethyl-5-(trifluoromethylsulfonyloxy)benzo[1,3]dioxin-4-one

: 709024-96-4
5-[4,5-bis(methoxymethoxy)-2-methylphenyl]-7-methoxy-2,2-dimethyl-4H-1,3-benzodioxin-4-one

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium bromide; In 1,4-dioxane; at 100 ℃;
DOI:10.1016/S0040-4039(03)00072-8

Reference yield:

: 18863-72-4
4-bromo-5-methylbenzene-1,2-diol

: 709024-96-4
5-[4,5-bis(methoxymethoxy)-2-methylphenyl]-7-methoxy-2,2-dimethyl-4H-1,3-benzodioxin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaH / dimethylformamide / 6 h / 0 °C

2: 95 percent / n-BuLi; (i-PrO)3B / tetrahydrofuran; hexane; diethyl ether / 4 h / -78 - 20 °C

3: 93 percent / KBr; K₃PO₄ / (Ph₃P)4Pd / dioxane / 10.5 h / 100 °C

With potassium phosphate; n-butyllithium; Triisopropyl borate; sodium hydride; potassium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; N,N-dimethyl-formamide; 3: Suzuki coupling reaction;
DOI:10.1016/j.tet.2004.05.017

Reference yield:

: 137571-73-4
5,7-dihydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: 709024-96-4
5-[4,5-bis(methoxymethoxy)-2-methylphenyl]-7-methoxy-2,2-dimethyl-4H-1,3-benzodioxin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 4.5 h / 0 - 20 °C

2: 94 percent / pyridine / 3.5 h / 0 °C

3: 93 percent / KBr; K₃PO₄ / (Ph₃P)4Pd / dioxane / 10.5 h / 100 °C

With pyridine; potassium phosphate; di-isopropyl azodicarboxylate; triphenylphosphine; potassium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1: Mitsunobu reaction / 3: Suzuki coupling reaction;
DOI:10.1016/j.tet.2004.05.017