4-PYRIDINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)-

Base Information

• Chemical Name: 4-PYRIDINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)-
• CAS No.: 915140-06-6
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.137
• Hs Code.: 2933399090
• Mol file: 915140-06-6.mol

Synonyms:2-Hydroxymethylisonicotinicacid

Chemical Property of 4-PYRIDINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)-

Chemical Property:

• PSA: 70.42000
• Density: 1.404
• LogP: 0.27210
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-(Hydroxymethyl)isonicotinicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-PYRIDINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)-

There total 3 articles about 4-PYRIDINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ethyl 2-(hydroxymethyl)pyridine-4-carboxylate (31804-60-1) → 2-(hydroxymethyl)isonicotinic acid (915140-06-6)

Guidance literature:

With water; potassium hydroxide; In tetrahydrofuran; at 100 ℃; for 20h;

DOI:10.1039/c5ra05564d

Reference yield: 61.0%

2-(ethoxycarbonyl)isonicotinic acid (142074-49-5) → 2-(hydroxymethyl)isonicotinic acid (915140-06-6)

Guidance literature:

With sodium tetrahydroborate; calcium chloride; In ethanol; at 80 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2015.03.063

Reference yield:

pyridine-2,4-dicarboxylic acid (499-80-9) → 2-(hydroxymethyl)isonicotinic acid (915140-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 80 °C / Inert atmosphere

2: sodium tetrahydroborate; calcium chloride / ethanol / 80 °C / Inert atmosphere

With sodium tetrahydroborate; toluene-4-sulfonic acid; calcium chloride; In ethanol; 1: |Fischer-Speier Esterification;

DOI:10.1016/j.bmc.2015.03.063

upstream raw materials:

ethyl 2-(hydroxymethyl)pyridine-4-carboxylate

pyridine-2,4-dicarboxylic acid

2-(ethoxycarbonyl)isonicotinic acid

Downstream raw materials:

2-Chloromethyl-4-cyanopyridine

2-hydroxymethyl-4-pyridinecarboxamide

Refernces

• 1、 Armaghan, Mahsa,Lu, W. Y. James,Wu, Di,Wei, Yao,Yuan, Feng-Ling,Ng, Seik Weng,Amini, Mostafa M.,Zhang, Wen-Hua,Young, David J.,Hor, T. S. Andy,Lang, Jian-Ping. "Isolation of first row transition metal-carboxylate zwitterions". . p. 42978 - 42989. Retrieved 2015/05/27.