3-PYRIDINECARBOXALDEHYDE, 2-CHLORO-5-(TRIFLUOROMETHYL)-

Base Information

• Chemical Name: 3-PYRIDINECARBOXALDEHYDE, 2-CHLORO-5-(TRIFLUOROMETHYL)-
• CAS No.: 934279-60-4
• Molecular Formula: C7H3 Cl F3 N O
• Molecular Weight: 209.55300
• Hs Code.: 2933399990
• Mol file: 934279-60-4.mol

Synonyms:2-Chloro-5-trifluoromethylpyridine-3-carboxaldehyde

Chemical Property of 3-PYRIDINECARBOXALDEHYDE, 2-CHLORO-5-(TRIFLUOROMETHYL)-

Chemical Property:

• Vapor Pressure: 0.055mmHg at 25°C
• Boiling Point: 233.821oC at 760 mmHg
• PKA: -4.07±0.10(Predicted)
• Flash Point: 95.212oC
• PSA: 29.96000
• Density: 1.499g/cm3
• LogP: 2.56630
• Storage Temp.: Room temperature.

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-3-formyl-5-trifluoromethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-PYRIDINECARBOXALDEHYDE, 2-CHLORO-5-(TRIFLUOROMETHYL)-

There total 1 articles about 3-PYRIDINECARBOXALDEHYDE, 2-CHLORO-5-(TRIFLUOROMETHYL)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-3-bromo-5-(trifluoromethyl)pyridine (71701-92-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-chloro-5-(trifluoromethyl)pyridine-3-carbaldehyde (934279-60-4)

Guidance literature:

With n-butyllithium; In hexane; toluene; at -65 ℃; for 0.5h;

Reference yield: 76.0%

2-chloro-5-(trifluoromethyl)pyridine-3-carbaldehyde (934279-60-4) → (2-chloro-5-(trifluoromethyl)pyridin-3-yl)methanol (943551-28-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 0.5h;

Reference yield:

2-chloro-5-(trifluoromethyl)pyridine-3-carbaldehyde (934279-60-4) + rac-(2R,3R,4R,5R)-ethyl 4-amino-3-(tert-butyl)-5-phenyl-1-((R)-tetrahydro-2H-pyran-2-carbonyl)pyrrolidine-2-carboxylate → rac-(2R,3R,4R,5R)-ethyl 3-(tert-butyl)-4-(((2-methoxy-5-(trifluoromethyl)pyridin-3-yl)methyl)amino)-5-phenyl-1-((R)-tetrahydro-2H-pyran-2-yl-carbonyl)pyrrolidine-2-carboxylate

Guidance literature:

2-chloro-5-(trifluoromethyl)pyridine-3-carbaldehyde; rac-(2R,3R,4R,5R)-ethyl 4-amino-3-(tert-butyl)-5-phenyl-1-((R)-tetrahydro-2H-pyran-2-carbonyl)pyrrolidine-2-carboxylate; With zinc(II) chloride; In methanol; at 20 ℃; for 0.166667h; pH=4;

With methanol; sodium cyanoborohydride; for 0.5h; pH=4;

upstream raw materials:

2-chloro-3-bromo-5-(trifluoromethyl)pyridine

N,N-dimethyl-formamide

Downstream raw materials:

(2-chloro-5-(trifluoromethyl)pyridin-3-yl)methanol

2-chloro-5-(trifluoromethyl)pyridin-3-ylmethane chloride

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