71701-92-3

Basic information

• Product Name: 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine
• Synonyms: 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine;5-Bromo-6-chloro-alpha,alpha,alpha-trifluoro-3-picoline;71701-92-3
• CAS NO: 71701-92-3
• Molecular Formula: C₆H₂BrClF₃N
• Molecular Weight: 260.44
• Product Categories: blocks;Bromides;FluoroCompounds;Pyridines;Fluorine series
• Mol File: 71701-92-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 28-32℃
• Boiling Point: 210.51 °C at 760 mmHg
• Flash Point: 98°(208°F)
• Appearance: Pale yellow to pale brown/Solid
• Density: 1.805 g/cm³
• Vapor Pressure: 0.278mmHg at 25°C
• Refractive Index: 1.493
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.34±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine(71701-92-3)
• EPA Substance Registry System: 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine(71701-92-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-36/37/38
• Safety Statements: 7/9-22-24/25-26-36/37-38-45-51
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 71701-92-3(Hazardous Substances Data)

Usage

General Description

3-Bromo-2-chloro-5-(trifluoromethyl)pyridine is a chemical compound with the molecular formula C6H3BrClF3N. It is a pyridine derivative with three substituent groups: bromine, chlorine, and a trifluoromethyl group. 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine is used in the synthesis of pharmaceuticals and agrochemicals due to its potential as a building block for more complex molecules. Its unique structure and reactivity make it a valuable intermediate in various chemical processes, especially in the production of heterocyclic compounds. Additionally, it is important to handle this compound with care, as it may pose health and environmental risks if not properly managed.

InChI:InChI=1/C6H2BrClF3N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H

Upstream product

• 76041-73-1 3-bromo-5-(trifluoromethyl)pyridin-2(1H)-one 
• 76041-73-1 3-bromo-5-(trifluoromethyl)pyridin-2-ol 
• 79456-30-7 3-bromo-5-trifluoromethyl-pyridin-2-ylamine 

Downstream Products

• 124432-63-9 3-bromo-2-methoxy-5-(trifluoromethyl)pyridine 
• 216765-95-6 3-bromo-N,N-dimethyl-5-(trifluoromethyl)pyridin-2-amine 
• 216766-05-1 3-bromo-2-ethoxy-5-(trifluoromethyl)pyridine 
• 1026086-96-3 2-chloro-5-(trifluoromethyl)pyridin-3-ylmethane chloride 
• 943551-28-8 (2-chloro-5-(trifluoromethyl)pyridin-3-yl)methanol 

Relevant articles and documents

HETEROCYCLIC DERIVATIVES AS CETP INHIBITORS

The present invention provides a compound of formula (I), said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.

PYRIDINYL AMINE DERIVATIVES AS INHIBITORS OF CHOLESTERYL ESTER TRANSFER PROTEIN (CETP)

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables are as defined, useful as inhibitors of chlosteryl ester transfer protein.

2,3,5-trisubstituted pyridines as inhibitors of cyclooxygenase-2

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.