(2,4,5-trichlorophenyl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]propanoate

Base Information

Chemical Name:(2,4,5-trichlorophenyl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]propanoate
CAS No.:244633-33-8
Molecular Formula:C₂₈H₂₆Cl₃NO₅
Molecular Weight:562.877
Hs Code.:
DSSTox Substance ID:DTXSID101117194
Nikkaji Number:J1.151.345J

Synonyms:DTXSID101117194;244633-33-8;O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine 2,4,5-trichlorophenyl ester

Suppliers and Price of (2,4,5-trichlorophenyl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2,4,5-trichlorophenyl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]propanoate

Chemical Property:

XLogP3:7.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:561.087656
Heavy Atom Count:37
Complexity:770

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OCC(C(=O)OC1=CC(=C(C=C1Cl)Cl)Cl)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
Isomeric SMILES:CC(C)(C)OC[C@@H](C(=O)OC1=CC(=C(C=C1Cl)Cl)Cl)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Technology Process of (2,4,5-trichlorophenyl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]propanoate

There total 2 articles about (2,4,5-trichlorophenyl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 71989-33-8
Fmoc-Ser(tBu)-OH

: 244633-30-5
4-nitro-benzenesulfonic acid 2,4,5-trichloro-phenyl ester

: 244633-33-8
Fmoc-Ser(t-Bu) 2,4,5-trichlorophenylester

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0040-4039(99)01178-8

Reference yield:

: 95-95-4
2,4,5-trichlorophenol

: 244633-33-8
Fmoc-Ser(t-Bu) 2,4,5-trichlorophenylester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / pyridine / 4 °C

2: 87 percent / HOBt; DIEA / dimethylformamide / 20 °C

With pyridine; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; 1: Esterification / 2: Esterification;
DOI:10.1016/S0040-4039(99)01178-8