methyl 7-(4-(4-methoxyphenyl)-1H-imidazol-1-yl)-5-methyl-2,3-dihydrobenzo[b]oxepine-4-carboxylate

Base Information

Chemical Name:methyl 7-(4-(4-methoxyphenyl)-1H-imidazol-1-yl)-5-methyl-2,3-dihydrobenzo[b]oxepine-4-carboxylate
CAS No.:1415003-58-5
Molecular Formula:C₂₃H₂₂N₂O₄
Molecular Weight:390.439
Hs Code.:

Synonyms:methyl 7-(4-(4-methoxyphenyl)-1H-imidazol-1-yl)-5-methyl-2,3-dihydrobenzo[b]oxepine-4-carboxylate

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Chemical Property of methyl 7-(4-(4-methoxyphenyl)-1H-imidazol-1-yl)-5-methyl-2,3-dihydrobenzo[b]oxepine-4-carboxylate

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Technology Process of methyl 7-(4-(4-methoxyphenyl)-1H-imidazol-1-yl)-5-methyl-2,3-dihydrobenzo[b]oxepine-4-carboxylate

There total 6 articles about methyl 7-(4-(4-methoxyphenyl)-1H-imidazol-1-yl)-5-methyl-2,3-dihydrobenzo[b]oxepine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1415003-30-3
methyl 7-bromo-5-methyl-2,3-dihydrobenzo[b]oxepine-4-carboxylate

: 35512-31-3
4-(4-methoxyphenyl)-1H-imidazole

: 1415003-58-5
methyl 7-(4-(4-methoxyphenyl)-1H-imidazol-1-yl)-5-methyl-2,3-dihydrobenzo[b]oxepine-4-carboxylate

Guidance literature:: With copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione; potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 20h; Inert atmosphere; Sealed flask;

Reference yield:

: 1450-75-5
5-Bromo-2-hydroxyacetophenone

: 1415003-58-5
methyl 7-(4-(4-methoxyphenyl)-1H-imidazol-1-yl)-5-methyl-2,3-dihydrobenzo[b]oxepine-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / butanone / 16 h / Reflux

2.1: sodium hydride / tetrahydrofuran / 20 h / 0 °C / Reflux

3.1: sodium hydride / mineral oil / 18.25 h / 20 - 80 °C

4.1: sodium hydride / 1,2-dimethoxyethane / 0.17 h / 0 °C / Inert atmosphere

4.2: 12 h / 0 - 20 °C

5.1: copper(l) iodide / diethyl ether; hexanes / 0.33 h / Cooling with salt-ice

5.2: 2 h / -78 - -40 °C

6.1: potassium carbonate; copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione / N,N-dimethyl-formamide / 20 h / 120 °C / Inert atmosphere; Sealed flask

With copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione; sodium hydride; potassium carbonate; In tetrahydrofuran; hexanes; 1,2-dimethoxyethane; diethyl ether; N,N-dimethyl-formamide; butanone; mineral oil;

Reference yield:

: 55580-08-0
7-bromo-3,4-dihydrobenzo[b]oxepin-5(2H)-one

: 1415003-58-5
methyl 7-(4-(4-methoxyphenyl)-1H-imidazol-1-yl)-5-methyl-2,3-dihydrobenzo[b]oxepine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil / 18.25 h / 20 - 80 °C

2.1: sodium hydride / 1,2-dimethoxyethane / 0.17 h / 0 °C / Inert atmosphere

2.2: 12 h / 0 - 20 °C

3.1: copper(l) iodide / diethyl ether; hexanes / 0.33 h / Cooling with salt-ice

3.2: 2 h / -78 - -40 °C

4.1: potassium carbonate; copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione / N,N-dimethyl-formamide / 20 h / 120 °C / Inert atmosphere; Sealed flask

With copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione; sodium hydride; potassium carbonate; In hexanes; 1,2-dimethoxyethane; diethyl ether; N,N-dimethyl-formamide; mineral oil;