4-(4-methoxyphenyl)-1H-imidazole

Base Information

• Chemical Name: 4-(4-methoxyphenyl)-1H-imidazole
• CAS No.: 35512-31-3
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.202
• DSSTox Substance ID: DTXSID90396484
• Nikkaji Number: J2.539.734G
• Wikidata: Q82197227
• ChEMBL ID: CHEMBL1583488
• Mol file: 35512-31-3.mol

Synonyms:4-(4-methoxyphenyl)-1H-imidazole;35512-31-3;5-(4-methoxyphenyl)-1H-imidazole;MFCD00461651;4-(4-methoxy-phenyl)-1H-imidazole;Bionet2_001066;MLS000763942;SCHEMBL872211;4-(p-methoxyphenyl)-imidazole;CHEMBL1583488;DTXSID90396484;WQROVAMZYXDXAB-UHFFFAOYSA-N;HMS1367A10;HMS2711N21;BBL028641;STL163857;AKOS005716429;SMR000336087;FT-0753075;EN300-139578;3T-0366

Chemical Property of 4-(4-methoxyphenyl)-1H-imidazole

Chemical Property:

• PSA: 37.91000
• LogP: 2.08530
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 174.079312947
• Heavy Atom Count: 13
• Complexity: 155

Purity/Quality:

99% ^*data from raw suppliers

4-(4-Methoxy-phenyl)-1H-imidazole 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CN=CN2

Technology Process of 4-(4-methoxyphenyl)-1H-imidazole

There total 16 articles about 4-(4-methoxyphenyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-benzyl-5-(4-methoxyphenyl)-1H-imidazole (1041845-36-6) → 4(5)-(4-methoxyphenyl)-1H-imidazole (35512-31-3)

Guidance literature:

With HC(O)ONH₄; palladium on activated charcoal; In methanol; for 48h; Heating;

DOI:10.1016/j.tet.2008.01.051

Reference yield: 91.0%

4-bromo-1 H-imidazole (2302-25-2) + 4-methoxyphenylboronic acid (5720-07-0) → 4-(4-methoxyphenyl)-1H-imidazole (35512-31-3)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; toluene; at 110 ℃; for 66h;

DOI:10.1021/jo701496p

Reference yield: 90.0%

(±)-N-(4-methoxybenzylidene)-2-methylpropane-2-sulfinamide (849590-39-2) + [(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) → 4(5)-(4-methoxyphenyl)-1H-imidazole (35512-31-3)

Guidance literature:

With potassium carbonate; In methanol; at 25 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2020.151705

upstream raw materials:

formaldehyd

p-methoxybenzoylmethanol

formamide

2-Bromo-4'-methoxyacetophenone

Downstream raw materials:

1-methyl-5-(4-methoxyphenyl)-1H-imidazole